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Netrin-4 binds DCC/UNC5A
Stable Identifier
R-HSA-593685
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
Netrin-4 binds DCC/UNC5A (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DCC and UNC5A, are also receptors for Netrin-4. The LNT domain of Netrin-4 is the key domain for this specific binding. Netrin-4 might also mediate attractive action through DCC and repulsive action through UNC5A.
Literature References
PubMed ID
Title
Journal
Year
17174565
Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains
Qin, S
,
Zhang, C
,
Gao, Y
,
Zhou, R
,
Yu, L
Mol Cell Neurosci
2007
Participants
Input
DCC, UNC5A [plasma membrane]
(Homo sapiens)
NTN4 [plasma membrane]
(Homo sapiens)
Output
NTN4:DCC,UNC5A [plasma membrane]
(Homo sapiens)
Participates
as an event of
Netrin-1 signaling (Homo sapiens)
Orthologous Events
Netrin-4 binds DCC/UNC5A (Bos taurus)
Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)
Netrin-4 binds DCC/UNC5A (Canis familiaris)
Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)
Netrin-4 binds DCC/UNC5A (Gallus gallus)
Netrin-4 binds DCC/UNC5A (Mus musculus)
Netrin-4 binds DCC/UNC5A (Rattus norvegicus)
Netrin-4 binds DCC/UNC5A (Sus scrofa)
Authored
Garapati, P V (2010-04-13)
Reviewed
Cooper, HM (2010-02-16)
Created
Garapati, P V (2010-04-13)
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