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PRKCH [cytosol]
Stable Identifier
R-HSA-58208
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, eta type , nPKC-eta, PKC-L
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin (Homo sapiens)
Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)
Keratinocyte PKCs [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Activation of Protein Kinase C novel isoforms (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
PKC binds active G alpha (z) (Homo sapiens)
G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
PKC phosphorylates G alpha (z) (Homo sapiens)
G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms:DAG [plasma membrane] (Homo sapiens)
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
PRKCH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24723 PRKCH
Gene Names
PRKCH, PKCL, PRKCL
Chain
chain:1-683
Reference Genes
BioGPS Gene:5583 PRKCH
COSMIC (genes):PRKCH PRKCH
CTD Gene:5583 PRKCH
dbSNP Gene:5583 PRKCH
ENSEMBL:ENSG00000027075 PRKCH
ENSEMBL_homo_sapiens_GENE:ENSG00000027075.17 PRKCH
KEGG Gene (Homo sapiens):5583 PRKCH
Monarch:5583 PRKCH
NCBI Gene:5583 PRKCH
OMIM:605437 PRKCH
UCSC:P24723 PRKCH
Reference Transcript
RefSeq:XM_017021458.1 PRKCH
RefSeq:NM_006255.4 PRKCH
Other Identifiers
11718809_a_at
11718810_at
11718811_s_at
1267_at
206099_PM_at
206099_at
218764_PM_at
218764_at
3538905
3538906
3538907
3538908
3538939
3538951
3538953
3538956
3538957
3538959
3538962
3538963
3538983
3539012
3539014
3539024
3539025
3539026
3539027
3539028
3539037
5583
58935_s_at
7974835
A_14_P131273
A_23_P205567
GE57971
GE82784
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0004699
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0006468
GO:0007165
GO:0010744
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0031267
GO:0034330
GO:0034351
GO:0035556
GO:0036211
GO:0043226
GO:0045618
GO:0046872
GO:0048856
GO:0050861
GO:0051092
GO:0060252
GO:0070062
GO:0070528
GO:0072659
GO:0080090
GO:0106310
GO:0140096
GO:1903078
GO:2000810
HMNXSV003014530
ILMN_1780898
M55284_at
PH_hs_0015962
TC14000371.hg
g13129041_3p_at
g5453971_3p_at
Participates
as a candidate of
Keratinocyte PKCs [cytosol] (Homo sapiens)
as a member of
Protein kinase C, novel isoforms [cytosol] (Homo sapiens)
Inferred To
PRKCH [cytosol]
(Bos taurus)
PRKCH [cytosol]
(Caenorhabditis elegans)
PRKCH [cytosol]
(Canis familiaris)
PRKCH [cytosol]
(Danio rerio)
PRKCH [cytosol]
(Dictyostelium discoideum)
PRKCH [cytosol]
(Drosophila melanogaster)
PRKCH [cytosol]
(Gallus gallus)
PRKCH [cytosol]
(Mus musculus)
PRKCH [cytosol]
(Rattus norvegicus)
PRKCH [cytosol]
(Saccharomyces cerevisiae)
PRKCH [cytosol]
(Schizosaccharomyces pombe)
Homologues of PRKCH [cytosol]
(Dictyostelium discoideum)
Homologues of PRKCH [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_016876947.1
,
NP_006246.2
ZINC - World Drugs
KPCL_HUMAN
Guide to Pharmacology - Targets
1487
OpenTargets
ENSG00000027075
ZINC - FDA approved
KPCL_HUMAN
ZINC - Substances
KPCL_HUMAN
ZINC target
P24723
ZINC - Biogenic
KPCL_HUMAN
PRO
P24723
PDB
3TXO
,
8FP1
,
2FK9
,
8FP3
ZINC - Investigational
KPCL_HUMAN
ZINC - Metabolites
KPCL_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000027075-PRKCH
GeneCards
P24723
Ensembl
ENSP00000329127
,
ENSP00000450981
,
ENST00000555082
,
ENSG00000027075
,
ENST00000332981
Pharos - Targets
P24723
ZINC - Predictions - Purchasable
KPCL_HUMAN
HMDB Protein
HMDBP01850
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