Reactome | CASP9(1-416) [cytosol]

CASP9(1-416) [cytosol]

Stable Identifier

R-HSA-57033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-9 precursor , CASP-9, ICE-like apoptotic protease 6, ICE-LAP6, Apoptotic protease Mch-6, Apoptotic protease activating factor 3, APAF-3

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External Reference Information

External Reference

UniProt:P55211 CASP9

Gene Names

CASP9, MCH6

Chain

propeptide:1-, chain:-315, propeptide:316-330, chain:331-416

Reference Genes

BioGPS Gene:842 CASP9

COSMIC (genes):CASP9 CASP9

CTD Gene:842 CASP9

dbSNP Gene:842 CASP9

ENSEMBL:ENSG00000132906 CASP9

HGNC:1511 CASP9

KEGG Gene (Homo sapiens):842 CASP9

Monarch:842 CASP9

NCBI Gene:842 CASP9

OMIM:602234 CASP9

UCSC:P55211 CASP9

Reference Transcript

Other Identifiers

0001770446

0006290010

11741401_a_at

11748782_a_at

1473

16681996

1JXQ

1NW9

203984_s_at

210775_x_at

2397697

2397698

2397699

2397700

2397701

2397702

2397703

2397704

2397706

2397708

2397711

2397713

2397714

2397717

2397718

2397719

2397721

2397722

240437_at

2AR9

3D9T

3V3K

3YGS

4348

46488

486_at

487_g_at

4RHW

5JUY

5WVC

5WVE

7912646

842

A0A087WX72

A_23_P97309

A_24_P111342

AAC50640

AAC50776

AAD12248

AAD13615

AAH02452

AAH06463

AAO21133

AAP35557

AAV33129

AB015653

AB019205

AB020979

AF093130

AF110376

AK303743

AL512883

AY214168

AY732490

BAA78780

BAA82697

BAA87905

BAG64715

BC002452

BC006463

BT006911

CAB004348

CASP9

CASP9-201

CASP9-202

CASP9-203

CCDS158

CCDS159

CCDS59995

CH471167

EAW51730

EAW51731

ENSG00000132906

ENSP00000255256

ENSP00000330237

ENSP00000365051

ENST00000333868

ENST00000333868.9

ENST00000348549

ENST00000348549.9

ENST00000375890

ENST00000375890.8

EntrezGene:842

EntrezGene:CASP9

F8VVS7

F8VWA5

g1532150_3p_s_at

g5103139_3p_s_at

GE59272

GO:0000902

GO:0001822

GO:0002376

GO:0002931

GO:0003674

GO:0004197

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006508

GO:0006915

GO:0006919

GO:0006950

GO:0006974

GO:0007165

GO:0007568

GO:0008047

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0008630

GO:0008635

GO:0009411

GO:0014070

GO:0016787

GO:0017124

GO:0019899

GO:0019901

GO:0030154

GO:0030220

GO:0030234

GO:0032025

GO:0032355

GO:0032496

GO:0032991

GO:0034349

GO:0034644

GO:0042770

GO:0042981

GO:0043065

GO:0043226

GO:0043293

GO:0043525

GO:0046677

GO:0048646

GO:0048856

GO:0071407

GO:0071549

GO:0071887

GO:0097153

GO:0097192

GO:0097199

GO:2001020

HGNC:1511

HPA001473

HPA046488

Hs.34174.1.A1_3p_at

ILMN_1718070

ILMN_1786046

IPR001309

IPR001315

IPR002138

IPR002398

IPR011029

IPR015917

IPR016129

IPR029030

IPR033139

IPR033171

MIM:602234

NM_001229

NM_001278054

NM_032996

NP_001220

NP_001264983

NP_127463

PF00619

PF00656

PH_hs_0023824

PR00376

Q5JRU2

Q5JRU8

SM00114

SM00115

U56390

U60521

U60521_at

UPI000002ABA2

UPI000012D14F

UPI0000D4DF43

XM_005246014

XP_005246071

Participant Of

hasCandidate

Long prodomain caspases [cytosol]

hasComponent

input

Other forms of this molecule

CASP9(?-315) [cytosol]

CASP9(331-416) [cytosol]

p-T125-CASP9(1-416) [cytosol]

CASP9(1-416) [cytosol]

p-S196-CASP9(1-416) [cytosol]

Inferred To

CASP9(1-416) [cytosol] (Bos taurus)

CASP9(1-416) [cytosol] (Caenorhabditis elegans)

CASP9(1-416) [cytosol] (Canis familiaris)

CASP9(1-416) [cytosol] (Danio rerio)

CASP9(1-416) [cytosol] (Drosophila melanogaster)

CASP9(1-416) [cytosol] (Gallus gallus)

CASP9(1-416) [cytosol] (Mus musculus)

CASP9(1-416) [cytosol] (Rattus norvegicus)

CASP9(1-416) [cytosol] (Sus scrofa)

CASP9(1-416) [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_005246071.1, NP_127463.2, NP_001264983.1, NP_001220.2

OpenTargets

ENSG00000132906

IntEnz

3.4.22.62

GeneCards

P55211

ZINC - Substances

CASP9_HUMAN

ZINC target

P55211

PRO

P55211

ZINC - Predictions - Purchasable

CASP9_HUMAN

PDB

5JUY, 3YGS, 1NW9, 2AR9, 1JXQ, 3D9T, 5WVE, 3V3K, 4RHW, 5WVC

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.965	21
UniProt:O14727 APAF1	4	APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [cytosol] (R-HSA-50099) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [secretory granule lumen] (R-HSA-6801271)	0.964	25
UniProt:Q96CA5 BIRC7			0.889	10
UniProt:Q13490 BIRC2	5	BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.883	9
UniProt:P42574 CASP3	5	CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.672	3
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344)	0.589	2
UniProt:P43146 DCC	4	DCC(26-1290) [plasma membrane] (R-HSA-373627) p-Y1420-DCC [plasma membrane] (R-HSA-374552) DCC(1291-1447) [cytosol] (R-HSA-373629) DCC [plasma membrane] (R-HSA-197560)	0.589	2
UniProt:Q13489 BIRC3	3	K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478) BIRC3 [cytosol] (R-HSA-50845)	0.573	2
IntAct:EBI-10214943 112401			0.556	3
UniProt:Q6PIA0 Q6PIA0			0.556	3
UniProt:Q8WYB5 KAT6B	1	KAT6B [nucleoplasm] (R-HSA-3318400)	0.488	2
IntAct:EBI-12872494 BIRC8			0.488	2