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COPS6 [nucleoplasm]
Stable Identifier
R-HSA-5697026
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
COP9 signalosome complex subunit 6, CSN6_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS6 [nucleoplasm] (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS6 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS6 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS6 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COP9 signalosome [nucleoplasm] (Homo sapiens)
COPS6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7L5N1 COPS6
Gene Names
COPS6, CSN6, HVIP
Chain
chain:1-327
Reference Genes
BioGPS Gene:10980 COPS6
COSMIC (genes):COPS6 COPS6
CTD Gene:10980 COPS6
dbSNP Gene:10980 COPS6
ENSEMBL:ENSG00000168090 COPS6
ENSEMBL_homo_sapiens_GENE:ENSG00000168090.10 COPS6
HGNC:21749 COPS6
KEGG Gene (Homo sapiens):10980 COPS6
Monarch:10980 COPS6
NCBI Gene:10980 COPS6
OMIM:614729 COPS6
UCSC:Q7L5N1 COPS6
Reference Transcript
RefSeq:NM_006833.4 COPS6
Other Identifiers
10980
11757481_a_at
17049103
201405_PM_s_at
201405_s_at
213504_PM_at
213504_at
3015217
3015218
3015219
3015221
3015224
3015226
3015228
3015230
3015232
3015233
3015235
3015236
3015237
3015238
40138_at
8134699
A_23_P8432
GE81686
GE86282
GO:0000338
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0008180
GO:0008233
GO:0008237
GO:0016787
GO:0032991
GO:0036211
GO:0043226
GO:0045116
GO:0048471
GO:0140096
GO:2000434
HMNXSV003029168
Hs.15591.1.S1_3p_at
ILMN_1764431
PH_hs_0040240
TC07000609.hg
U70735_at
g5803095_3p_a_at
Participates
as a component of
COP9 signalosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
COPS6 [cytosol]
Inferred To
COPS6 [nucleoplasm]
(Bos taurus)
COPS6 [nucleoplasm]
(Canis familiaris)
COPS6 [nucleoplasm]
(Sus scrofa)
cops6 [nucleoplasm]
(Xenopus tropicalis)
csn-6 [nucleoplasm]
(Caenorhabditis elegans)
Cops6 [nucleoplasm]
(Mus musculus)
Cops6 [nucleoplasm]
(Rattus norvegicus)
Homologues of COPS6 [nucleoplasm]
(Sus scrofa)
CSN6 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of COPS6 [nucleoplasm]
(Danio rerio)
Ghost homologue of COPS6 [nucleoplasm]
(Gallus gallus)
Ghost homologue of COPS6 [nucleoplasm]
(Schizosaccharomyces pombe)
csn6 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_006824.2
OpenTargets
ENSG00000168090
HPA
ENSG00000168090-COPS6
GeneCards
Q7L5N1
Ensembl
ENSP00000304102
,
ENST00000303904
,
ENSG00000168090
PRO
Q7L5N1
Pharos - Targets
Q7L5N1
PDB
8H3F
,
6R6H
,
4WSN
,
6R7H
,
4D10
,
4QFT
,
8H3A
,
6R7I
,
4D18
,
4R14
,
6R7F
,
8H38
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.669
6
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.669
6
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.667
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.653
7
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.623
11
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.564
2
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.564
8
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.564
5
UniProt:Q15048 LRRC14
1
LRRC14 [cytosol]
(R-HSA-9749455)
0.564
5
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.564
7
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.564
3
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.544
2
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
2
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.527
2
UniProt:O94844 RHOBTB1
1
RHOBTB1 [endosome membrane]
(R-HSA-194899)
0.527
5
UniProt:Q8NHY2 RFWD2
3
p-S387-RFWD2 [cytosol]
(R-HSA-349439)
RFWD2 [nucleoplasm]
(R-HSA-349454)
p-S387-RFWD2 [nucleoplasm]
(R-HSA-349450)
0.525
3
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