Reactome | COPS4 [nucleoplasm]

COPS4 [nucleoplasm]

Stable Identifier

R-HSA-5697020

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP9 signalosome complex subunit 4, CSN4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BT78 COPS4

Gene Names

COPS4, CSN4

Chain

initiator methionine:, chain:2-406

Reference Genes

BioGPS Gene:51138 COPS4

COSMIC (genes):COPS4 COPS4

CTD Gene:51138 COPS4

dbSNP Gene:51138 COPS4

ENSEMBL:ENSG00000138663 COPS4

ENSEMBL_homo_sapiens_GENE:ENSG00000138663.9 COPS4

HGNC:16702 COPS4

KEGG Gene (Homo sapiens):51138 COPS4

Monarch:51138 COPS4

NCBI Gene:51138 COPS4

OMIM:616008 COPS4

UCSC:Q9BT78 COPS4

Reference Transcript

Other Identifiers

11743307_a_at

11743308_s_at

16968407

218042_PM_at

218042_at

2733929

2733930

2733934

2733935

2733937

2733938

2733942

2733943

2733945

2733948

2733949

2733951

2733952

2733953

2733954

46232_at

51138

8096098

A_14_P105040

A_14_P122108

A_23_P340457

A_23_P43779

GE82082

GO:0000338

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008021

GO:0008180

GO:0016607

GO:0016787

GO:0019784

GO:0030054

GO:0031410

GO:0031982

GO:0032991

GO:0036211

GO:0043226

GO:0045116

GO:0045202

GO:0140096

GO:2000434

HMNXSV003024896

ILMN_1726755

PH_hs_0000671

TC04000458.hg

g7705844_3p_at

Participates

as a component of

COP9 signalosome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

COPS4 [cytosol]

Inferred To

CSN4 [nucleoplasm] (Drosophila melanogaster)

csn4 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of COPS4 [nucleoplasm] (Canis familiaris)

Ghost homologue of COPS4 [nucleoplasm] (Schizosaccharomyces pombe)

cops4 [nucleoplasm] (Danio rerio)

cops4 [nucleoplasm] (Xenopus tropicalis)

COPS4 [nucleoplasm] (Bos taurus)

COPS4 [nucleoplasm] (Gallus gallus)

COPS4 [nucleoplasm] (Sus scrofa)

csn-4 [nucleoplasm] (Caenorhabditis elegans)

Cops4 [nucleoplasm] (Mus musculus)

Cops4 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001317656.1, NP_001244935.1, NP_057213.2

OpenTargets

ENSG00000138663

GeneCards

Q9BT78

HPA

ENSG00000138663-COPS4

Ensembl

ENSP00000425976, ENSG00000138663, ENSP00000264389, ENST00000509093, ENST00000264389

PRO

Q9BT78

Pharos - Targets

Q9BT78

PDB

6R6H, 6R7N, 6R7H, 4D18, 4D10, 8H3A, 6R7F, 4WSN, 8H38, 6R7I, 8H3F, 4D0P

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.669	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.527	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.524	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.462	6

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