Association of RAD51 with RAD52:DNA double-strand break ends

Stable Identifier
R-HSA-5693564
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RAD52 can simultaneously interact with RAD51 and RPA. The interaction with RAD51 may inhibit the formation of the invading RAD51 filament by sequestering RAD51 from RPA, thus promoting single strand annealing (SSA) instead of homologous recombination (Chen et al. 1999, Stark et al. 2004, Singleton et al. 2002, Mansour et al. 2008). The interaction of RAD51 and RAD52 is promoted by ABL1-mediated phosphorylation of both RAD51 and RAD52 (Chen et al. 1999, Van Dyck et al. 1999), which also increases RAD52 affinity for DNA (Honda et al. 2011).

Literature References
PubMed ID Title Journal Year
18539610 Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

Mansour, WY, Schumacher, S, Rosskopf, R, Rhein, T, Schmidt-Petersen, F, Gatzemeier, F, Haag, F, Borgmann, K, Willers, H, Dahm-Daphi, J

Nucleic Acids Res. 2008
15485900 Genetic steps of mammalian homologous repair with distinct mutagenic consequences

Stark, JM, Pierce, AJ, Oh, J, Pastink, A, Jasin, M

Mol. Cell. Biol. 2004
10438626 Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52.

Baumann, P, West, SC

J Mol Biol 1999
10212258 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

Chen, G, Yuan, SS, Liu, W, Xu, Y, Trujillo, K, Song, B, Cong, F, Goff, SP, Wu, Y, Arlinghaus, R, Baltimore, D, Gasser, PJ, Park, MS, Sung, P, Lee, EY

J Biol Chem 1999
9837724 Visualisation of human rad52 protein and its complexes with hRad51 and DNA.

Van Dyck, E, Hajibagheri, NM, Stasiak, A, West, SC

J Mol Biol 1999
12370410 Structure of the single-strand annealing domain of human RAD52 protein.

Singleton, MR, Wentzell, LM, Liu, Y, West, SC, Wigley, DB

Proc Natl Acad Sci U S A 2002
21804533 Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

Honda, M, Okuno, Y, Yoo, J, Ha, T, Spies, M

EMBO J. 2011
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