Reactome | p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

Stable Identifier

R-HSA-5692781

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAPK6 and MAPKAPK5 bind to the GDP-exchange factor KALRN, also known as Kalirin-7 or KAL7 (Brand et al, 2012). CaMKII-dependent phosphorylation of KALRN7 results in activation of PAK kinases in dendritic spines, potentially establishing a positive feedback loop that governs the MAPK6:MAPKAPK5 module in neuronal developement (Penzes et al, 2003; Xie et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
18031682	Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines Penzes, P, Kai, L, Surmeier, DJ, Photowala, H, Cahill, ME, Srivastava, DP, Woolfrey, KM, Xie, Z, Shum, CY	Neuron	2007
12546821	Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin Penzes, P, Eipper, BA, Schiller, MR, Huganir, RL, Chernoff, J, Beeser, A, Mains, RE	Neuron	2003
22508986	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology Schumacher, S, Brand, F, Kant, S, Meloche, S, Kotlyarov, A, Gaestel, M, Menon, MB, Turgeon, B, Simon, R, Britsch, S	Mol. Cell. Biol.	2012