CUL1, SKP1, FBXL5 bind

Stable Identifier
R-HSA-5691167
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex comprising the F-box/LRR-repeat protein 5 (FBXL5) protein, S-phase kinase-associated protein 1 (SKP1), cullin 1 (CUL1) and NEDD8. This complex targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Here, CUL1, FBXF5 and SKP1 bind.

Literature References
PubMed ID Title Journal Year
19762597 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

Salahudeen, AA, Thompson, JW, Ruiz, JC, Ma, HW, Kinch, LN, Li, Q, Grishin, NV, Bruick, RK

Science 2009
19762596 Control of iron homeostasis by an iron-regulated ubiquitin ligase

Vashisht, AA, Zumbrennen, KB, Huang, X, Powers, DN, Durazo, A, Sun, D, Bhaskaran, N, Persson, A, Uhlén, M, Sangfelt, O, Spruck, C, Leibold, EA, Wohlschlegel, JA

Science 2009
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