Reactome | ACO1:4Fe-4S isomerises CIT to ISCIT

ACO1:4Fe-4S isomerises CIT to ISCIT

Stable Identifier

R-HSA-5690911

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytoplasmic aconitate hydratase (ACO1, iron regulatory protein 1, IRP1) functions either as an RNA binding protein that regulates the uptake, sequestration, and utilisation of iron or an enzyme that isomerises citrate to isocitrate, depending on changes in cellular iron levels. Under iron-replete conditions, ACO1 binds the cofactor 4Fe-4S cluster and acts as an aconitase, isomerising citrate (CIT) to isocitrate (ISCIT) (Kaptain et al. 1991, Philpott et al. 1994, Dupuy et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16407072	Crystal structure of human iron regulatory protein 1 as cytosolic aconitase Fontecilla-Camps, JC, Darnault, C, Carpentier, P, Volbeda, A, Dupuy, J, Moulis, JM	Structure	2006
1946430	A regulated RNA binding protein also possesses aconitase activity Haile, D, Downey, WE, Orloff, DG, Harford, JB, Philpott, C, Kaptain, S, Klausner, RD, Rouault, TA, Tang, C	Proc. Natl. Acad. Sci. U.S.A.	1991
8041788	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation Philpott, CC, Klausner, RD, Rouault, TA	Proc. Natl. Acad. Sci. U.S.A.	1994
25550467	Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis Ortega, F, Moreno-Navarrete, JM, Fernández-Real, JM, Moreno, M, Xifra, G, Ricart, W	FASEB J	2015