UCHL3, SENP8 cleave NEDD8

Stable Identifier
R-HSA-5690808
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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UCHL3, SENP8 cleave NEDD8
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UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NEDD8 propeptides, exposing a C-terminal Gly residue. UCHL3 can also process ubiquitin (Wada et al. 1998). UCHL3 and SENP8 are probably functionally redundant in NEDD8 processing as deletion of either enzyme does not lead to neddylation defects (Chan et al. 2008, Kurihara et al. 2000).
Literature References
PubMed ID Title Journal Year
9790970 Cleavage of the C-terminus of NEDD8 by UCH-L3

Kamitani, T, Wada, H, Yeh, ET, Caskey, LS, Kito, K

Biochem. Biophys. Res. Commun. 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

deNEDDylase activity of UCHL3,SENP8:NEDD8(1-88) [cytosol]

Physical Entity
UCHL3,SENP8:NEDD8(1-88) [cytosol] (Homo sapiens)
Activity
deNEDDylase activity (GO:0019784)
Orthologous Events
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
UCHL3, SENP8 cleave NEDD8 (Mus musculus)
UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)
UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)
UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)
UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)
UCHL3, SENP8 cleave NEDD8 (Sus scrofa)
UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-30)
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