Histone H2A is dubiquitinated by the PR-DUB complex

Stable Identifier
R-HSA-5690790
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Histone H2A is dubiquitinated by the PR-DUB complex
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BAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).
Literature References
PubMed ID Title Journal Year
20436459 Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Scheuermann, JC, Müller, J, Wilm, M, Fraterman, S, de Ayala Alonso, AG, Ly-Hartig, N, Muir, TW, Oktaba, K, McGinty, RK

Nature 2010
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Catalyst Activity

cysteine-type deubiquitinase activity of PR-DUB complex [nucleoplasm]

Physical Entity
PR-DUB complex [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)
Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)
Histone H2A is dubiquitinated by the PR-DUB complex (Drosophila melanogaster)
Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)
Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)
Histone H2A is dubiquitinated by the PR-DUB complex (Rattus norvegicus)
Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)
Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-30)
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