Josephin domain DUBs

Stable Identifier
R-HSA-5689877
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Josephin domain DUBs
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The Josephin domain is present in four human DUBs: Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) and JOSD2. All have been shown to possess DUB activity (Tzveltkov & Breuer 2007, Weeks et al. 2011). Josephin domain DUBs may specialize in distinguishing between polyubiquitin chains of different lengths (Eletr & Wilkinson 2014).
Literature References
PubMed ID Title Journal Year
23845989 Regulation of proteolysis by human deubiquitinating enzymes

Wilkinson, KD, Eletr, ZM

Biochim. Biophys. Acta 2014
Participants
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Orthologous Events
Josephin domain DUBs (Bos taurus)
Josephin domain DUBs (Caenorhabditis elegans)
Josephin domain DUBs (Canis familiaris)
Josephin domain DUBs (Danio rerio)
Josephin domain DUBs (Dictyostelium discoideum)
Josephin domain DUBs (Drosophila melanogaster)
Josephin domain DUBs (Gallus gallus)
Josephin domain DUBs (Mus musculus)
Josephin domain DUBs (Plasmodium falciparum)
Josephin domain DUBs (Rattus norvegicus)
Josephin domain DUBs (Saccharomyces cerevisiae)
Josephin domain DUBs (Schizosaccharomyces pombe)
Josephin domain DUBs (Sus scrofa)
Josephin domain DUBs (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-24)
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