Reactome | GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-5689804

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13987 CD59

Gene Names

CD59, MIC11, MIN1, MIN2, MIN3, MSK21

Chain

signal peptide:1-25, chain:26-102, propeptide:103-128

Reference Genes

BioGPS Gene:966 CD59

COSMIC (genes):CD59 CD59

CTD Gene:966 CD59

dbSNP Gene:966 CD59

ENSEMBL:ENSG00000085063 CD59

ENSEMBL_homo_sapiens_GENE:ENSG00000085063.18 CD59

HGNC:1689 CD59

KEGG Gene (Homo sapiens):966 CD59

Monarch:966 CD59

NCBI Gene:966 CD59

OMIM:107271 CD59

Reference Transcript

Other Identifiers

11718100_s_at

11718101_at

11718102_at

11757306_s_at

16737194

16737200

200983_PM_x_at

200983_x_at

200984_PM_s_at

200984_s_at

200985_PM_s_at

200985_s_at

212463_PM_at

212463_at

228748_PM_at

228748_at

3368706

3368708

3368709

3368710

3368711

3368712

3368713

3368714

3368715

3368716

3368717

3368718

3368719

3368720

3368721

3368722

3368723

3368724

3368725

3368726

3368727

3368728

3368729

3368730

3368734

3368737

3368738

3368739

3368740

3368741

3368742

3368743

3368745

3368746

3368747

39170_at

39351_at

62133_at

7947425

966

A_23_P75523

A_24_P141481

A_24_P639441

A_24_P784765

A_33_P3409746

GE56215

GE79480

GE88415

GO:0000139

GO:0001848

GO:0001971

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005925

GO:0007166

GO:0007596

GO:0009897

GO:0009986

GO:0012507

GO:0016020

GO:0023052

GO:0030133

GO:0030449

GO:0031410

GO:0031982

GO:0033116

GO:0035579

GO:0042060

GO:0043226

GO:0070062

GO:0070821

GO:0098552

GO:1903659

HMNXSV003026907

HMNXSV003054760

Hs.119663.0.S1_3p_a_at

Hs.119663.0.S2_3p_a_at

Hs.293774.0.A1_3p_at

Hs.99766.0.S1_3p_at

ILMN_1669659

ILMN_1724789

ILMN_2333687

M84349_at

PH_hs_0014290

TC11001540.hg

TC11003112.hg

TC11003113.hg

g10835164_3p_a_at

Participates

as a member of

GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Other forms of this molecule

CD59 [specific granule membrane]

CD59 [tertiary granule membrane]

GPI-CD59 [ER to Golgi transport vesicle membrane]

GPI-CD59 [endoplasmic reticulum membrane]

GPI-CD59 [transport vesicle]

GPI-CD59 [Golgi membrane]

CD59 [plasma membrane]

Inferred To

CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Cd59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)

Cd59b [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

Modified Residues

Name

L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 102

Coordinate

102

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-asparagine amide

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to L-asparagine amide.

Cross References

RefSeq

NP_976076.1, NP_001120695.1, NP_000602.1, NP_001120698.1, NP_976074.1, NP_976075.1, NP_001120699.1, NP_001120697.1

OpenTargets

ENSG00000085063

HPA

ENSG00000085063-CD59

GeneCards

P13987

Ensembl

ENST00000651785, ENST00000652678, ENSP00000379191, ENSP00000494884, ENST00000351554, ENSP00000403511, ENSP00000498448, ENST00000437761, ENSP00000404822, ENSP00000340210, ENST00000445143, ENST00000415002, ENST00000395850, ENSP00000432942, ENSP00000498879, ENSP00000410182, ENST00000642928, ENSG00000085063, ENST00000527577

PRO

P13987

Pharos - Targets

P13987

Orphanet

18955

PDB

8B0F, 1CDS, 4BIK, 2UX2, 1ERG, 5IMT, 2J8B, 8B0H, 1CDQ, 1CDR, 5IMY, 2OFS, 8B0G, 6ZD0, 2UWR, 1ERH

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	9
UniProt:Q15363 TMED2	5	TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [Golgi membrane] (R-HSA-6808804) TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531)	0.576	4
UniProt:O35587 TMEDA			0.576	5
UniProt:Q5JX71 F209A			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q778I9 Q778I9			0.537	4