PARK2 autoubiquitinates

Stable Identifier
R-HSA-5689111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ubiquitin conjugates linked via lysine-48 (K48) target substrates to the proteasome, whereas those linked via any of the six other ubiquitin lysines can alter the function of the modified protein without leading to degradation. Parkin (PARK2) was found to autoubiquitinate itself predominantly via K6, K27, K29 and K63-linked ubiquitination, rather than via K48 (Durcan et al. 2011).

Literature References
PubMed ID Title Journal Year
20940148 The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

Durcan, TM, Kontogiannea, M, Thorarinsdottir, T, Fallon, L, Williams, AJ, Djarmati, A, Fantaneanu, T, Paulson, HL, Fon, EA

Hum. Mol. Genet. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of PARK2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created