Reactome | DHX15 [nucleoplasm]

DHX15 [nucleoplasm]

Stable Identifier

R-HSA-5688097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 ecNumber3.6.4.13/ecNumber, DHX15_HUMAN, hPrp43

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43143 DHX15

Gene Names

DHX15, DBP1, DDX15

Chain

chain:1-795

Reference Genes

BioGPS Gene:1665 DHX15

COSMIC (genes):DHX15 DHX15

CTD Gene:1665 DHX15

dbSNP Gene:1665 DHX15

ENSEMBL:ENSG00000109606 DHX15

ENSEMBL_homo_sapiens_GENE:ENSG00000109606.13 DHX15

HGNC:2738 DHX15

KEGG Gene (Homo sapiens):1665 DHX15

Monarch:1665 DHX15

NCBI Gene:1665 DHX15

OMIM:603403 DHX15

UCSC:O43143 DHX15

Reference Transcript

RefSeq:NM_001358.2 DHX15

Other Identifiers

11743114_at

1665

16974873

201385_PM_at

201385_at

201386_PM_s_at

201386_s_at

2763813

2763814

2763815

2763816

2763817

2763820

2763824

2763827

2763828

2763829

2763830

2763831

2763833

2763835

2763836

2763842

2763843

2763845

2763846

2763847

2763848

2763849

2763850

2763851

2763852

2763853

35306_at

8099649

A_23_P69826

GE53029

GO:0000166

GO:0000398

GO:0002376

GO:0003676

GO:0003723

GO:0003724

GO:0003725

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0005689

GO:0005730

GO:0006397

GO:0008186

GO:0008380

GO:0009636

GO:0016071

GO:0016607

GO:0016787

GO:0016887

GO:0023052

GO:0042742

GO:0043123

GO:0043226

GO:0043279

GO:0045087

GO:0051607

GO:0071008

GO:0098542

GO:0140098

GO:0140374

GO:0140657

HMNXSV003003878

ILMN_1754839

ILMN_2168449

PH_hs_0000577

TC04001086.hg

g4557516_3p_at

g9624452_3p_a_at

Participates

as an output of

Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)

as a component of

as an input of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Inferred To

Ghost homologue of DHX15 [nucleoplasm] (Danio rerio)

DHX15 [nucleoplasm] (Bos taurus)

DHX15 [nucleoplasm] (Caenorhabditis elegans)

DHX15 [nucleoplasm] (Canis familiaris)

DHX15 [nucleoplasm] (Dictyostelium discoideum)

DHX15 [nucleoplasm] (Drosophila melanogaster)

DHX15 [nucleoplasm] (Gallus gallus)

DHX15 [nucleoplasm] (Mus musculus)

DHX15 [nucleoplasm] (Plasmodium falciparum)

DHX15 [nucleoplasm] (Schizosaccharomyces pombe)

DHX15 [nucleoplasm] (Sus scrofa)

dhx15 [nucleoplasm] (Xenopus tropicalis)

Dhx15 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001349.2

OpenTargets

ENSG00000109606

IntEnz

3.6.4.13

GeneCards

O43143

HPA

ENSG00000109606-DHX15

Ensembl

ENSG00000109606, ENST00000336812, ENSP00000336741

PRO

O43143

Pharos - Targets

O43143

HMDB Protein

HMDBP11694

PDB

6SH7, 5XDR, 6ID1, 6SH6, 8EJM

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N5A5-2 ZGPAT			0.85	12
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.844	11
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.806	15
UniProt:O15226 NKRF			0.666	4
UniProt:Q8N5A5 ZGPAT			0.666	6
UniProt:Q96RS6 NUDC1			0.643	4
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.632	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.597	4
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q8N302 AGGF1	2	AGGF(1-290)-RAF1(279-648) fusion [cytosol] (R-HSA-6802255) AGGF(1-290)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802507)	0.556	3
UniProt:A0A0S2Z6H0 A0A0S2Z6H0			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q9P1Y5-2 Q9P1Y52			0.556	3
UniProt:Q86XP3 DDX42	1	DDX42 [nucleoplasm] (R-HSA-8867894)	0.547	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	2
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	2
UniProt:Q8N1G2 CMTR1			0.527	2
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	2
UniProt:Q8IWZ8 SUGP1	1	SUGP1 [nucleoplasm] (R-HSA-72043)	0.508	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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