Reactome | RAD23A [nucleoplasm]

RAD23A [nucleoplasm]

Stable Identifier

R-HSA-5688076

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

UV excision repair protein RAD23 homolog A, HR23A

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - UV-DDB ubiquitinates XPC (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - XPC binds RAD23 and CETN2 (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - CHD1L is recruited to GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - Recruitment of XPA and release of CAK (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
      - TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        RAD23 [nucleoplasm] (Homo sapiens)
        
        RAD23A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54725 RAD23A

Gene Names

RAD23A

Chain

chain:1-363

Reference Genes

BioGPS Gene:5886 RAD23A

COSMIC (genes):RAD23A RAD23A

CTD Gene:5886 RAD23A

dbSNP Gene:5886 RAD23A

ENSEMBL:ENSG00000179262 RAD23A

ENSEMBL_homo_sapiens_GENE:ENSG00000179262.10 RAD23A

HGNC:9812 RAD23A

KEGG Gene (Homo sapiens):5886 RAD23A

Monarch:5886 RAD23A

NCBI Gene:5886 RAD23A

OMIM:600061 RAD23A

UCSC:P54725 RAD23A

Reference Transcript

Other Identifiers

11716020_s_at

11716021_x_at

11748360_s_at

11757537_x_at

16858788

1753_s_at

201039_PM_s_at

201039_s_at

201046_PM_s_at

201046_s_at

3822075

3822076

3822080

3822081

3822082

3822083

3822085

3822086

3822087

3822090

3822092

3822093

3822094

3822095

41197_at

55661_f_at

5886

8026122

AD000092_cds7_s_at

A_33_P3362193

D21235_at

GO:0000502

GO:0003677

GO:0003684

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006281

GO:0006289

GO:0006974

GO:0019900

GO:0030163

GO:0031593

GO:0031648

GO:0032434

GO:0032436

GO:0032991

GO:0033554

GO:0043130

GO:0043161

GO:0043226

GO:0043231

GO:0045070

GO:0045787

GO:0070628

GO:1990381

HMNXSV003021998

Hs.180455.0.A1_3p_a_at

ILMN_1751571

PH_hs_0025819

TC19000233.hg

g4826963_3p_a_at

Participates

as a member of

RAD23 [nucleoplasm] (Homo sapiens)

as a candidate of

RAD23 [nucleoplasm] (Homo sapiens)

Inferred To

rhp23 [nucleoplasm] (Schizosaccharomyces pombe)

Rad23 [nucleoplasm] (Drosophila melanogaster)

Rad23a [nucleoplasm] (Mus musculus)

Rad23a [nucleoplasm] (Rattus norvegicus)

rcbA [nucleoplasm] (Dictyostelium discoideum)

RAD23 [nucleoplasm] (Saccharomyces cerevisiae)

rad23a [nucleoplasm] (Danio rerio)

rad-23 [nucleoplasm] (Caenorhabditis elegans)

RAD23A [nucleoplasm] (Bos taurus)

RAD23A [nucleoplasm] (Canis familiaris)

RAD23A [nucleoplasm] (Gallus gallus)

RAD23A [nucleoplasm] (Plasmodium falciparum)

RAD23A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001257291.1, NP_005044.1, NP_001257292.1

OpenTargets

ENSG00000179262

HPA

ENSG00000179262-RAD23A

GeneCards

P54725

Ensembl

ENST00000592268, ENST00000316856, ENST00000586534, ENSG00000179262, ENSP00000467024, ENSP00000468674, ENSP00000321365

PRO

P54725

Pharos - Targets

P54725

PDB

1QZE, 6XQI, 7TGP, 1P9D, 1TP4, 1IFY, 6W2G, 1P98, 1F4I, 6XQJ, 1OQY, 6W2H, 2WYQ, 1DV0, 6W2I, 5XBO

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.83	8
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.666	9
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.635	3
UniProt:Q6FIF0 ZFAND6	1	ZFAND6 [cytosol] (R-HSA-9033138)	0.556	3
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) Ub-48-UBA52(1-76) [lysosomal membrane] (R-HSA-9762994) Ub-48-UBA52(1-76) [endocytic vesicle membrane] (R-HSA-9763054) UBA52(1-76) [endosome membrane] (R-HSA-939189) UBA52(1-76) [plasma membrane] (R-HSA-3149452) RPL40 [cytosol] (R-HSA-72476) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082)	0.556	3
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.556	5
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.556	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.556	3
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.556	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
UniProt:Q01831 XPC	5	Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.524	2