MYC mRNA translation is negatively regulated by miR-34B and C

Stable Identifier
R-HSA-5687113
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MYC mRNA translation is negatively regulated by miR-34B and C
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Translation of MYC mRNA is negatively regulated by miR-34B and C microRNAs (Kress et al, 2011). miR-34 miRNAs bind and cause degradation of MYC mRNA, resulting in decreased level of MYC protein product (reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Eilers, M, Roepman, P, Bushell, M, Samans, B, Cannell, IG, Rosenwald, A, Gaestel, M, Burgering, BM, Brenkman, AB

Mol. Cell 2011
21329875 More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

Myant, K, Sansom, OJ

Mol. Cell 2011
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Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
miR-34B,C RISC [cytosol] (Homo sapiens)
Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Seternes, OM  (2015-05-05)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-04-06)
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