IGF2BP1 represses translation of MAPK4 mRNA

Stable Identifier
R-HSA-5687105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of IGF2BP1 to the 3' UTR of MAPK4 mRNA inhibits its translation and in this way antagonizes the MAPKAPK5-dependent phosphorylation of HSBP1 (Stohr et al, 2012; Kostenko et al, 2009a; reviewed in Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
19166925 PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

Kostenko, S, Johannessen, M, Moens, U

Cell. Signal. 2009
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
22279049 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling

Stöhr, N, Köhn, M, Lederer, M, Glass, M, Reinke, C, Singer, RH, Hüttelmaier, S

Genes Dev. 2012
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created