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Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Stable Identifier
R-HSA-5686483
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
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The identity of DNA ligases that ligate DNA strands generated during cleavage of Holliday junctions by GEN1 or the SLX-MUS complex (composed of SLX1A:SLX4 heterodimer and MUS81:EME1 or possibly MUS81:EME2 heterodimer) is not known. The resolvase activity of GEN1 or SLX-MUS predominantly results in the generation of crossover products, with exchange of genetic material between sister chromatids (Wyatt et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
24076221
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells
West, SC
,
Matos, J
,
Sarbajna, S
,
Wyatt, HD
Mol. Cell
2013
Participants
Input
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
(Homo sapiens)
Output
BCDX2 complex [nucleoplasm]
(Homo sapiens)
CX3 complex [nucleoplasm]
(Homo sapiens)
dsDNA with crossover [nucleoplasm]
EXO1,DNA2:BLM,WRN [nucleoplasm]
(Homo sapiens)
KAT5 [nucleoplasm]
(Homo sapiens)
p-5S-BRCA1:p-2T-BARD1 [nucleoplasm]
(Homo sapiens)
p-MRN [nucleoplasm]
(Homo sapiens)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(Homo sapiens)
p-S327,T847,T859-RBBP8 homotetramer [nucleoplasm]
(Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(Homo sapiens)
PALB2 [nucleoplasm]
(Homo sapiens)
RAD51AP1 [nucleoplasm]
(Homo sapiens)
SEM1:p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm]
(Homo sapiens)
Sister Chromatid Arm with Crossover [nucleoplasm]
Participates
as an event of
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
Authored
Orlic-Milacic, M (2015-05-12)
Matthews, L (2003-11-23)
Reviewed
Borowiec, JA (2015-06-12)
Created
Orlic-Milacic, M (2015-04-02)
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