CHEK1 phosphorylates RAD51

Stable Identifier
R-HSA-5685230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Activated CHEK1 phosphorylates RAD51 on threonine residue T309, which is necessary for RAD51 association with chromatin (Sorensen et al. 2005).

Literature References
PubMed ID Title Journal Year
15665856 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Sørensen, CS, Hansen, LT, Dziegielewski, J, Syljuåsen, RG, Lundin, C, Bartek, J, Helleday, T

Nat. Cell Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created