Reactome | SH2D1B [cytosol]

SH2D1B [cytosol]

Stable Identifier

R-HSA-5685187

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2 domain-containing protein 1B, SH21B_HUMAN, EAT2, Ewing's sarcoma-associated transcript (EAT2)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14796 SH2D1B

Gene Names

SH2D1B, EAT2

Chain

chain:1-132

Reference Genes

BioGPS Gene:117157 SH2D1B

COSMIC (genes):SH2D1B SH2D1B

CTD Gene:117157 SH2D1B

dbSNP Gene:117157 SH2D1B

ENSEMBL:ENSG00000198574 SH2D1B

ENSEMBL_homo_sapiens_GENE:ENSG00000198574.6 SH2D1B

HGNC:30416 SH2D1B

KEGG Gene (Homo sapiens):117157 SH2D1B

Monarch:117157 SH2D1B

NCBI Gene:117157 SH2D1B

OMIM:608510 SH2D1B

UCSC:O14796 SH2D1B

Reference Transcript

RefSeq:NM_053282.4 SH2D1B

Other Identifiers

117157

11740155_a_at

11740156_a_at

11740157_at

11749207_a_at

1553176_PM_at

1553176_at

1553177_PM_at

1553177_at

16695769

2441221

2441222

2441223

2441225

2441227

2441228

2441229

7921900

A_23_P351148

A_32_P324533

GE474407

GO:0002250

GO:0002366

GO:0002376

GO:0002717

GO:0005515

GO:0005829

GO:0030674

GO:0045087

GO:0045089

GO:0060090

GO:0098542

HMNXSV003011112

Hs2.350581.1.S1_3p_at

Hs2.350581.1.S2_3p_at

ILMN_1701237

PH_hs_0016895

PH_hs_0032781

TC01003455.hg

Participates

as a member of

SAP,EAT2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_444512.2

OpenTargets

ENSG00000198574

HPA

ENSG00000198574-SH2D1B

GeneCards

O14796

Ensembl

ENSP00000356906, ENSG00000198574, ENST00000367929

PRO

O14796

Pharos - Targets

O14796

PDB

5KAZ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.688	7
UniProt:Q96DU3 SLAMF6	1	SLAMF6 [plasma membrane] (R-HSA-197848)	0.623	4
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.556	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.556	3
UniProt:Q9UIB8 CD84	1	CD84 [plasma membrane] (R-HSA-3325587)	0.527	3
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.525	2
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.525	2
UniProt:Q14765 STAT4	4	p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.488	2

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