Reactome | TRAPPC2L [cytosol]

TRAPPC2L [cytosol]

Stable Identifier

R-HSA-5683759

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSPC126, TRAPP2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        TRAPPCs [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)
        
        TRAPPCIII [cytosol] (Homo sapiens)
        
        TRAPPC2L [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UL33 TRAPPC2L

Gene Names

TRAPPC2L, HSPC126

Chain

chain:1-140

Reference Genes

BioGPS Gene:51693 TRAPPC2L

COSMIC (genes):TRAPPC2L TRAPPC2L

CTD Gene:51693 TRAPPC2L

dbSNP Gene:51693 TRAPPC2L

ENSEMBL:ENSG00000167515 TRAPPC2L

ENSEMBL_homo_sapiens_GENE:ENSG00000167515.11 TRAPPC2L

HGNC:30887 TRAPPC2L

KEGG Gene (Homo sapiens):51693 TRAPPC2L

Monarch:51693 TRAPPC2L

NCBI Gene:51693 TRAPPC2L

OMIM:610970 TRAPPC2L

UCSC:Q9UL33 TRAPPC2L

Reference Transcript

Other Identifiers

11756392_a_at

11764016_a_at

16821882

218354_PM_at

218354_at

238627_3p_at

238627_PM_at

238627_at

238628_PM_s_at

238628_s_at

3673724

3673725

3673727

3673732

3673734

3673737

3673738

3673739

3673740

45737_at

51693

76146_at

7997852

88601_at

A_14_P116809

A_24_P150676

A_24_P327050

GE58702

GO:0005515

GO:0005634

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005829

GO:0006888

GO:0006901

GO:0016192

GO:0030008

GO:0031410

GO:0043226

GO:0043231

GO:0048208

GO:0048471

GO:0061024

GO:0065003

GO:0099022

GO:1990071

GO:1990072

HMNXSV003030656

Hs.116876.1.A1_3p_a_at

Hs.116876.1.A1_3p_at

ILMN_1747058

ILMN_1859908

PH_hs_0023314

PH_hs_0038791

TC16000687.hg

g7706428_3p_at

p25991

Participates

as a component of

Inferred To

RGD1564492 [cytosol] (Rattus norvegicus)

trappc2l [cytosol] (Dictyostelium discoideum)

trappc2l [cytosol] (Xenopus tropicalis)

Trappc2l [cytosol] (Mus musculus)

Trappc2l [cytosol] (Rattus norvegicus)

Dmel\CG9067 [cytosol] (Drosophila melanogaster)

zgc:172319 [cytosol] (Danio rerio)

Homologues of TRAPPC2L [cytosol] (Rattus norvegicus)

TRAPPC2L [cytosol] (Bos taurus)

TRAPPC2L [cytosol] (Caenorhabditis elegans)

TRAPPC2L [cytosol] (Canis familiaris)

TRAPPC2L [cytosol] (Gallus gallus)

TRAPPC2L [cytosol] (Plasmodium falciparum)

TRAPPC2L [cytosol] (Schizosaccharomyces pombe)

TRAPPC2L [cytosol] (Sus scrofa)

TCA17 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001305454.1, NP_001305456.1, NP_001305458.1, NP_001305453.1, NP_001305455.1, NP_001305457.1, NP_001305461.1, NP_001305459.1, NP_057293.1

OpenTargets

ENSG00000167515

GeneCards

Q9UL33

HPA

ENSG00000167515-TRAPPC2L

Ensembl

ENST00000301021, ENSG00000167515, ENSP00000512526, ENSP00000301021, ENST00000696289

PRO

Q9UL33

Pharos - Targets

Q9UL33

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.638	3

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