Reactome | TRAPPC2 [cytosol]

TRAPPC2 [cytosol]

Stable Identifier

R-HSA-5683757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SEDL, TRAPP1, TRAPP2, TRAPP3, TRAPP core

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        TRAPPCs [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)
        
        TRAPPCIII [cytosol] (Homo sapiens)
        
        TRAPPC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0DI81 TRAPPC2

Gene Names

TRAPPC2, SEDL

Chain

chain:1-140

Reference Genes

BioGPS Gene:6399 TRAPPC2

COSMIC (genes):TRAPPC2 TRAPPC2

CTD Gene:6399 TRAPPC2

dbSNP Gene:6399 TRAPPC2

ENSEMBL:ENSG00000196459 TRAPPC2

ENSEMBL_homo_sapiens_GENE:ENSG00000196459.15 TRAPPC2

HGNC:23068 TRAPPC2

KEGG Gene (Homo sapiens):6399 TRAPPC2

Monarch:6399 TRAPPC2

NCBI Gene:6399 TRAPPC2

OMIM:300202 TRAPPC2

UCSC:P0DI81 TRAPPC2

Reference Transcript

Other Identifiers

11724432_x_at

11753721_s_at

17109153

209751_PM_s_at

209751_s_at

219351_PM_at

219351_at

3843193

3843194

3843196

3843197

3843198

3843199

3843200

4000129

4000131

4000133

4000134

4000135

4000136

4000138

4000140

4000141

4000142

4000146

4000151

4000152

4032417

4032469

4032490

4036889

4036924

48534_at

6399

8171352

A_23_P73660

GE58601

GO:0001501

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005783

GO:0005793

GO:0005794

GO:0005829

GO:0006888

GO:0006901

GO:0016192

GO:0030008

GO:0031410

GO:0043226

GO:0043231

GO:0044325

GO:0048208

GO:0048471

GO:0048856

GO:0061024

GO:0065003

GO:0099022

GO:1990071

GO:1990072

HMNXSV003011792

HMNXSV003036668

ILMN_1673275

ILMN_1705218

ILMN_2408440

TC0X000867.hg

g7657547_3p_at

g9937492_3p_s_at

Participates

as a component of

Inferred To

Trappc2 [cytosol] (Mus musculus)

Trappc2 [cytosol] (Rattus norvegicus)

Trs20 [cytosol] (Drosophila melanogaster)

trs20 [cytosol] (Schizosaccharomyces pombe)

TRS20 [cytosol] (Saccharomyces cerevisiae)

TRAPPC2 [cytosol] (Bos taurus)

TRAPPC2 [cytosol] (Canis familiaris)

TRAPPC2 [cytosol] (Gallus gallus)

TRAPPC2 [cytosol] (Plasmodium falciparum)

TRAPPC2 [cytosol] (Sus scrofa)

sedl-1 [cytosol] (Caenorhabditis elegans)

trappc2 [cytosol] (Danio rerio)

trappc2 [cytosol] (Dictyostelium discoideum)

trappc2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001011658.1, NP_055378.1, XP_011543868.1, NP_001122307.2, XP_011543867.1

OpenTargets

ENSG00000196459

HPA

ENSG00000196459-TRAPPC2

GeneCards

P0DI81

Ensembl

ENSG00000196459, ENST00000359680, ENST00000380579, ENST00000518847, ENST00000458511, ENST00000683569, ENST00000683983, ENSP00000508155, ENSP00000392495, ENSP00000369953, ENSP00000507474, ENSP00000352708, ENSP00000428900

PRO

P0DI81

Pharos - Targets

P0DI81

Orphanet

15654

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.558	3
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [cytosol] (R-HSA-8935900) EPS15L1 [plasma membrane] (R-HSA-182937)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3

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