ATG12:ATG7:CysO572-ATG7 binds ATG10

Stable Identifier
R-HSA-5682893
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ATG12:ATG7:CysO572-ATG7 binds ATG10
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The N-terminal domain of ATG7 recruits the E2-like protein ATG10 (Kaiser et al. 2012, Yamaguchi et al. 2012). Biochemical data and modeling suggest that recruitment of ATG10 to the ATG7 N-terminal domain results in presentation of the ATG10 active site to the ATG7-ATG12 thioester linkage from the opposing monomer in the ATG7 homodimer (Klionsky & Schulman 2014).
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Orthologous Events
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Canis familiaris)
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Mus musculus)
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)
ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-11)
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