Reactome | HERC2 and PIAS4 are recruited to DNA DSBs

HERC2 and PIAS4 are recruited to DNA DSBs

Stable Identifier

R-HSA-5682586

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HERC2 and PIAS4 are recruited to DNA DSBs

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PIAS4, an E3 SUMO ligase, is recruited to DNA double-strand breaks (DSBs) via an unknown mechanism that requires a DNA-binding SAP domain of PIAS4 (Galanty et al. 2009). HERC2, an E3 ubiquitin ligase and a PIAS4 target, is recruited to DNA DSBs probably through its interaction with ATM (Bekker-Jensen et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20016603	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R	Nature	2009
20023648	HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes Lukas, J, Gromova, I, Rendtlew Danielsen, J, Bartek, J, Nerstedt, A, Lukas, C, Fugger, K, Bekker-Jensen, S, Mailand, N	Nat. Cell Biol.	2010