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UIMC1 [nucleoplasm]
Stable Identifier
R-HSA-5682574
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BRCA1-A complex subunit RAP80, RAP80, Receptor-associated protein 80, RXRIP110, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1
Locations in the PathwayBrowser for interactor UniProt:P38398%20BRCA1
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)
UIMC1 [nucleoplasm] (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
RNF4 ubiquitinates MDC1 (Homo sapiens)
UIMC1 [nucleoplasm] (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
UIMC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RL1 UIMC1
Gene Names
UIMC1, RAP80, RXRIP110
Chain
chain:1-719
Reference Genes
BioGPS Gene:51720 UIMC1
COSMIC (genes):UIMC1 UIMC1
CTD Gene:51720 UIMC1
dbSNP Gene:51720 UIMC1
ENSEMBL:ENSG00000087206 UIMC1
ENSEMBL_homo_sapiens_GENE:ENSG00000087206.17 UIMC1
HGNC:30298 UIMC1
KEGG Gene (Homo sapiens):51720 UIMC1
Monarch:51720 UIMC1
NCBI Gene:51720 UIMC1
OMIM:609433 UIMC1
UCSC:Q96RL1 UIMC1
Reference Transcript
RefSeq:XM_005265936.2 UIMC1
RefSeq:XM_017009578.1 UIMC1
RefSeq:XM_005265930.2 UIMC1
RefSeq:NM_001199298.1 UIMC1
RefSeq:XM_017009574.1 UIMC1
RefSeq:NM_001199297.2 UIMC1
RefSeq:XM_006714871.2 UIMC1
RefSeq:NM_016290.4 UIMC1
RefSeq:NM_001317961.1 UIMC1
RefSeq:XM_017009579.1 UIMC1
Other Identifiers
11743336_a_at
17003151
220746_PM_s_at
220746_s_at
2888520
2888521
2888522
2888523
2888525
2888528
2888531
2888533
2888546
2888547
2888549
2888550
2888551
2888560
2888561
2888562
2888564
2888568
2888569
2888573
2888579
2888580
2888582
51720
54987_at
8115978
GE58720
GO:0000278
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006282
GO:0006302
GO:0006325
GO:0006351
GO:0006355
GO:0006974
GO:0007095
GO:0010212
GO:0016604
GO:0023052
GO:0035861
GO:0042393
GO:0043226
GO:0044818
GO:0045739
GO:0045892
GO:0046872
GO:0061649
GO:0070530
GO:0070531
GO:0140861
HMNXSV003008626
ILMN_1691188
PH_hs_0023597
TC05002101.hg
TC05003365.hg
g7706482_3p_s_at
Participates
as an output of
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
RNF4 ubiquitinates MDC1 (Homo sapiens)
as a component of
p-5S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] (Homo sapiens)
as an input of
UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)
Inferred To
Ghost homologue of UIMC1 [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of UIMC1 [nucleoplasm]
(Xenopus tropicalis)
UIMC1 [nucleoplasm]
(Bos taurus)
UIMC1 [nucleoplasm]
(Canis familiaris)
UIMC1 [nucleoplasm]
(Gallus gallus)
UIMC1 [nucleoplasm]
(Mus musculus)
UIMC1 [nucleoplasm]
(Rattus norvegicus)
UIMC1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_016865068.1
,
XP_016865067.1
,
NP_001186226.1
,
NP_057374.3
,
XP_006714934.1
,
XP_005265987.1
,
NP_001304890.1
,
XP_016865063.1
,
XP_005265993.1
,
NP_001186227.1
OpenTargets
ENSG00000087206
HPA
ENSG00000087206-UIMC1
GeneCards
Q96RL1
Ensembl
ENST00000511320
,
ENSP00000423717
,
ENSG00000087206
,
ENST00000506128
,
ENSP00000427480
,
ENST00000510698
,
ENSP00000366434
,
ENST00000377227
,
ENSP00000421926
PRO
Q96RL1
Pharos - Targets
Q96RL1
PDB
2MKF
,
2MKG
,
2RR9
,
2N9E
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.78
13
UniProt:Q6UWZ7 FAM175A
1
p-S406-FAM175A [nucleoplasm]
(R-HSA-5682575)
0.688
9
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.668
4
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