PP5 dephosphorylates RAF1 S338

Stable Identifier
R-HSA-5675433
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).
Literature References
PubMed ID Title Journal Year
16892053 Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

Grindlay, GJ, Dhillon, AS, Kolch, W, Pitt, A, von Kriegsheim, A

Nat. Cell Biol. 2006
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PPP5C [cytosol]

Orthologous Events
Authored
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Created
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