Reactome | DUSP6 [cytosol]

DUSP6 [cytosol]

Stable Identifier

R-HSA-5675343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dual specificity protein phosphatase 6 ecNumber3.1.3.16/ecNumber ecNumber3.1.3.48/ecNumber, DUS6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16828 DUSP6

Gene Names

DUSP6, MKP3, PYST1

Chain

chain:1-381

Reference Genes

BioGPS Gene:1848 DUSP6

COSMIC (genes):DUSP6 DUSP6

CTD Gene:1848 DUSP6

dbSNP Gene:1848 DUSP6

ENSEMBL:ENSG00000139318 DUSP6

ENSEMBL_homo_sapiens_GENE:ENSG00000139318.8 DUSP6

HGNC:3072 DUSP6

KEGG Gene (Homo sapiens):1848 DUSP6

Monarch:1848 DUSP6

NCBI Gene:1848 DUSP6

OMIM:602748 DUSP6

UCSC:Q16828 DUSP6

Reference Transcript

Other Identifiers

11722049_a_at

11741980_a_at

11744435_a_at

11744618_a_at

16768297

1848

208891_PM_at

208891_at

208892_PM_s_at

208892_s_at

208893_PM_s_at

208893_s_at

3464870

3464871

3464872

3464873

3464874

3464877

3464880

3464881

3464882

3464883

3464884

41193_at

7965335

A_23_P139704

GE81092

GO:0000165

GO:0001933

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0008138

GO:0008330

GO:0009410

GO:0010033

GO:0012501

GO:0014070

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0023052

GO:0030154

GO:0033550

GO:0035335

GO:0036211

GO:0043065

GO:0043226

GO:0043409

GO:0048856

GO:0051409

GO:0060420

GO:0070371

GO:0070373

GO:0070848

GO:0140096

HMNXSV003054108

ILMN_1677466

ILMN_2396020

PH_hs_0023584

TC12001796.hg

X93920_at

g13111942_3p_at

g13477170_3p_a_at

Participates

as a member of

cytosolic MAPK DUSPs [cytosol] (Homo sapiens)

Other forms of this molecule

DUSP6 [nucleoplasm]

Inferred To

dusp6 [cytosol] (Xenopus tropicalis)

Dusp6 [cytosol] (Mus musculus)

Dusp6 [cytosol] (Rattus norvegicus)

DUSP6 [cytosol] (Bos taurus)

DUSP6 [cytosol] (Canis familiaris)

DUSP6 [cytosol] (Gallus gallus)

DUSP6 [cytosol] (Plasmodium falciparum)

DUSP6 [cytosol] (Sus scrofa)

Mkp3 [cytosol] (Drosophila melanogaster)

lip-1 [cytosol] (Caenorhabditis elegans)

mkp3 [cytosol] (Danio rerio)

mpl3 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001937.2, NP_073143.2

OpenTargets

ENSG00000139318

IntEnz

3.1.3.48

HPA

ENSG00000139318-DUSP6

GeneCards

Q16828

ZINC target

Q16828

Ensembl

ENSP00000279488, ENST00000308385, ENSG00000139318, ENSP00000307835, ENST00000279488

PRO

Q16828

Pharos - Targets

Q16828

Orphanet

22158

HMDB Protein

HMDBP08913

PDB

1MKP, 1HZM

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.758	5
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.744	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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