Reactome | BRAP binds KSR1:MARK3

BRAP binds KSR1:MARK3

Stable Identifier

R-HSA-5674019

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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BRAP is a negative regulator of MAPK signaling that binds KSR1 as assessed by coimmunoprecipitation. This interaction abrogates KSR1 homodimer and KSR1:RAF heterodimer formation, and disrupts the recruitment of MAP2K kinases to RAF (Methany et al, 2004; Chen et al, 2008; reviewed in Methany et al, 2009). BRAP inhibition of KSR1 is relieved in an unknown manner by autoubiquitination after RAS pathway activation (reviewed in Methany et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
14724641	Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP White, MA, Kortum, RL, Lewis, RE, Razidlo, GL, Matheny, SA, Chen, C	Nature	2004
18332145	IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds White, MA, Lewis, RE, Chen, C	J. Biol. Chem.	2008
19091743	Signaling threshold regulation by the Ras effector IMP White, MA, Matheny, SA	J. Biol. Chem.	2009