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Go!
ub-BRAP [cytosol]
Stable Identifier
R-HSA-5674001
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
BRAP autoubiquitinates (Homo sapiens)
p21 RAS:GTP:ub-BRAP [plasma membrane] (Homo sapiens)
ub-BRAP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z569 BRAP
Gene Names
BRAP, RNF52
Chain
chain:1-592
Reference Genes
BioGPS Gene:8315 BRAP
COSMIC (genes):BRAP BRAP
CTD Gene:8315 BRAP
dbSNP Gene:8315 BRAP
ENSEMBL:ENSG00000089234 BRAP
ENSEMBL_homo_sapiens_GENE:ENSG00000089234.16 BRAP
HGNC:1099 BRAP
KEGG Gene (Homo sapiens):8315 BRAP
Monarch:8315 BRAP
NCBI Gene:8315 BRAP
OMIM:604986 BRAP
UCSC:Q7Z569 BRAP
Reference Transcript
RefSeq:NM_006768.4 BRAP
Other Identifiers
11724633_at
11751151_a_at
16770256
209922_PM_at
209922_at
209923_PM_s_at
209923_s_at
213473_PM_at
213473_at
3471701
3471703
3471705
3471706
3471707
3471708
3471709
3471710
3471711
3471712
3471713
3471724
3471726
3471727
3471728
3471729
3471730
3471733
3471734
35500_at
41512_PM_at
41512_at
63075_s_at
7966427
8315
A_23_P53614
GE54285
GO:0000151
GO:0000165
GO:0003676
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0006807
GO:0007265
GO:0008139
GO:0008270
GO:0009968
GO:0016567
GO:0016740
GO:0023052
GO:0031965
GO:0036211
GO:0042802
GO:0043170
GO:0043226
GO:0044238
GO:0046872
GO:0061630
GO:0140096
HMNXSV003015347
Hs.122764.1.S1_3p_s_at
PH_hs_0025720
TC12001974.hg
g3252871_3p_a_at
Participates
as a component of
p21 RAS:GTP:ub-BRAP [plasma membrane] (Homo sapiens)
Other forms of this molecule
BRAP [cytosol]
Inferred To
F1NJH4 [cytosol]
(Gallus gallus)
Dmel\CG5555 [cytosol]
(Drosophila melanogaster)
brap [cytosol]
(Xenopus tropicalis)
Brap [cytosol]
(Rattus norvegicus)
Q95QN6 [cytosol]
(Caenorhabditis elegans)
zgc:92894 [cytosol]
(Danio rerio)
BRAP [cytosol]
(Bos taurus)
BRAP [cytosol]
(Canis familiaris)
BRAP [cytosol]
(Sus scrofa)
Q99MP8 [cytosol]
(Mus musculus)
Modified Residues
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_006759.3
OpenTargets
ENSG00000089234
GeneCards
Q7Z569
HPA
ENSG00000089234-BRAP
Ensembl
ENSP00000403524
,
ENSG00000089234
,
ENST00000419234
PRO
Q7Z569
Pharos - Targets
Q7Z569
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z569 BRAP
2
ub-BRAP [cytosol]
(R-HSA-5674001)
BRAP [cytosol]
(R-HSA-5672938)
0.573
2
UniProt:Q9BW85 YJU2
1
YJU2 [nucleoplasm]
(R-HSA-9770430)
0.556
3
UniProt:Q5JVL4 EFHC1
0.547
2
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.524
3
UniProt:O75969 AKAP3
0.508
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.508
3
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