Reactome | 26Sproteasome degrades K48polyUb-NIK

26Sproteasome degrades K48polyUb-NIK

Stable Identifier

R-HSA-5668520

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Polyubiquitinated NIK is targeted for proteasomal degradation and as a consequence the NIK levels are invisible and thus prevent non-canonical NF-kB activation.

Literature References

PubMed ID	Title	Journal	Year
18997794	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK Mahoney, DJ, Wang, Y, Shiba, T, Mak, TW, Yeh, WC, Cheng, G, Dempsey, PW, He, J, Cheung, HH, Korneluk, RG, Yang, X, Zarnegar, BJ	Nat. Immunol.	2008
10797013	Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli Yang, Y, Weissman, AM, Ashwell, JD, Jensen, JP, Fang, S	Science	2000