NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors

Stable Identifier
R-HSA-5663258
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NR1D1 (REV-ERBA) binds heme and the promoter of the PGC-1alpha (PPARGC1A) gene. The REV-ERBA:heme complex recruits the corepressors NCoR and HDAC3 and represses transcription.

Literature References
PubMed ID Title Journal Year
19710360 Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha

Wu, N, Yin, L, Hanniman, EA, Joshi, S, Lazar, MA

Genes Dev 2009
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