SNCAIP binds alpha-synuclein

Stable Identifier
R-HSA-5658104
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Reaction
Species
Homo sapiens
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Synphilin-1 (SNCAIP) binds alpha-synuclein (SNCAs) in vivo, which promotes the formation of Lewy body-like inclusions that are characteristic of Parkinson's Disease (Engelender et al. 1999, Kawamata et al. 2001). SNCAIP and PARK2 (Parkin) are found in the central core of a majority of Lewy Bodies in Parkinson's disease (Bandopadhyay et al. 2005).

Literature References
PubMed ID Title Journal Year
10319874 Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Engelender, S, Kaminsky, Z, Guo, X, Sharp, AH, Amaravi, RK, Kleiderlein, JJ, Margolis, RL, Troncoso, JC, Lanahan, AA, Worley, PF, Dawson, VL, Dawson, TM, Ross, CA

Nat. Genet. 1999
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