Reactome | VCP [nucleoplasm]

VCP [nucleoplasm]

Stable Identifier

R-HSA-5643745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p97 ATPase, Transitional endoplasmic reticulum ATPase, TERA_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Damage Bypass (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Translesion Synthesis by POLH (Homo sapiens)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)
        
        NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
        
        NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)
      - SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Homo sapiens)
        
        NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)
        
        NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Homo sapiens)
        
        NPLOC4:UFD1L:VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Josephin domain DUBs (Homo sapiens)
      - ATXN3 binds VCP (Homo sapiens)
        
        ATXN3:VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)
        
        VCP hexamer [nucleoplasm] (Homo sapiens)
        
        VCP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55072 VCP

Gene Names

VCP

Chain

initiator methionine:1, chain:2-806

Reference Genes

BioGPS Gene:7415 VCP

COSMIC (genes):VCP VCP

CTD Gene:7415 VCP

dbSNP Gene:7415 VCP

ENSEMBL:ENSG00000165280 VCP

HGNC:12666 VCP

KEGG Gene (Homo sapiens):7415 VCP

Monarch:7415 VCP

NCBI Gene:7415 VCP

OMIM:601023 VCP

Reference Transcript

RefSeq:NM_007126.3 VCP

Other Identifiers

0007100136

11733010_a_at

11745875_x_at

11746412_x_at

11758451_s_at

12728

12814

17093570

208648_at

208649_s_at

3204407

3204408

3204409

3204410

3204412

3204414

3204415

3204417

3204419

3204420

3204421

3204422

3204423

3204425

3204426

3204429

3204430

3204432

3204433

3204435

3204437

3204440

3204441

3204454

33818_at

3EBB

3HU1

3HU2

3HU3

3QC8

3QQ7

3QQ8

3QWZ

3TIW

44058_at

4KDI

4KDL

4KLN

4KO8

4KOD

4P0A

5593

56348_at

5B6C

5C18

5C19

5C1A

5C1B

5DYG

5DYI

5EPP

5FTJ

5FTK

5FTL

5FTM

5FTN

5GLF

5IFS

5IFW

5KIW

5KIY

5X4L

7415

8160914

A_23_P83045

A_24_P127828

A_24_P295412

AAC07984

AAD43016

AAI10914

AAI21795

AC004472

ACI46036

ACI46044

AF100752

AK312310

AL353795

BAG35235

BC110913

BC121794

C9IZA5

C9JUP7

CAA94809

CAB005593

CCDS6573

CH471071

EAW58404

ENSG00000165280

ENSP00000351777

ENST00000358901

ENST00000358901.10

EntrezGene:7415

EntrezGene:VCP

FJ224344

FJ224352

g5410289_3p_a_at

GE54792

GE79640

GO:0000166

GO:0000278

GO:0000502

GO:0002376

GO:0003674

GO:0003723

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005811

GO:0005829

GO:0006091

GO:0006259

GO:0006281

GO:0006302

GO:0006457

GO:0006464

GO:0006511

GO:0006734

GO:0006810

GO:0006888

GO:0006914

GO:0006919

GO:0006950

GO:0006974

GO:0007010

GO:0007034

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008289

GO:0009056

GO:0009058

GO:0010494

GO:0010498

GO:0010918

GO:0016192

GO:0016236

GO:0016567

GO:0016579

GO:0016787

GO:0016887

GO:0018279

GO:0019079

GO:0019899

GO:0019903

GO:0019904

GO:0019985

GO:0022607

GO:0030234

GO:0030433

GO:0030968

GO:0030970

GO:0031334

GO:0031410

GO:0031593

GO:0031625

GO:0032436

GO:0032510

GO:0032991

GO:0034098

GO:0034214

GO:0034605

GO:0034641

GO:0034655

GO:0034774

GO:0035578

GO:0035617

GO:0035800

GO:0035861

GO:0036435

GO:0036503

GO:0036513

GO:0042288

GO:0042802

GO:0042981

GO:0043161

GO:0043167

GO:0043226

GO:0043231

GO:0043312

GO:0043531

GO:0044281

GO:0044389

GO:0044403

GO:0044877

GO:0045184

GO:0045202

GO:0045732

GO:0046034

GO:0048471

GO:0050807

GO:0051186

GO:0051228

GO:0051260

GO:0055085

GO:0061857

GO:0065003

GO:0070062

GO:0070842

GO:0070987

GO:0071712

GO:0072389

GO:0090263

GO:0097352

GO:0098978

GO:1903006

GO:1903007

GO:1903715

GO:1903843

GO:1903862

GO:1904288

GO:1904813

GO:1904949

GO:1990381

GO:1990730

GO:2000158

GO:2001171

HEL-S-70

HGNC:12666

HPA012728

HPA012814

Hs.106357.0.S2_3p_at

ILMN_1665376

ILMN_1777220

IPR003338

IPR003593

IPR003959

IPR003960

IPR004201

IPR005938

IPR009010

IPR015415

IPR027417

IPR029067

IPR041569

LRG_657

MIM:167320

MIM:601023

MIM:613954

MIM:616687

NM_001354927

NM_001354928

NM_007126

NP_001341856

NP_001341857

NP_009057

PF00004

PF02359

PF02933

PF09336

PF17862

PH_hs_0024763

SM00382

SM01072

SM01073

TC09001048.hg

TC09002468.hg

UPI000005FB2E

V9HW80

VCP

VCP-201

Z70768

Participant Of

hasComponent

VCP hexamer [nucleoplasm]

Other forms of this molecule

Me3K315-VCP [cytosol]

VCP [endoplasmic reticulum membrane]

VCP [cytosol]

VCP [secretory granule lumen]

VCP [azurophil granule lumen]

VCP [extracellular region]

VCP [ficolin-1-rich granule lumen]

Inferred To

VCP [nucleoplasm] (Caenorhabditis elegans)

VCP [nucleoplasm] (Canis familiaris)

VCP [nucleoplasm] (Danio rerio)

VCP [nucleoplasm] (Dictyostelium discoideum)

VCP [nucleoplasm] (Drosophila melanogaster)

VCP [nucleoplasm] (Gallus gallus)

VCP [nucleoplasm] (Mus musculus)

VCP [nucleoplasm] (Plasmodium falciparum)

VCP [nucleoplasm] (Rattus norvegicus)

VCP [nucleoplasm] (Saccharomyces cerevisiae)

VCP [nucleoplasm] (Schizosaccharomyces pombe)

VCP [nucleoplasm] (Xenopus tropicalis)

Homologues of VCP [nucleoplasm] (Gallus gallus)

Ghost homologue of VCP [nucleoplasm] (Bos taurus)

Ghost homologue of VCP [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_009057.1

OpenTargets

ENSG00000165280

GeneCards

P55072

ZINC - Substances

TERA_HUMAN

ZINC target

P55072

PRO

P55072

Orphanet

15706

ZINC - Predictions - Purchasable

TERA_HUMAN

PDB

6G2Z, 5C18, 3HU3, 5C19, 4KDL, 3TIW, 5KIW, 3HU2, 5FTJ, 5DYG, 6MCK, 3HU1, 3EBB, 5IFS, 5KIY, 4KDI, 5EPP, 5FTK, 3QWZ, 5X4L, 5DYI, 5FTL, 5IFW, 4P0A, 4KOD, 5C1A, 3QC8, 5B6C, 5C1B, 6G2V, 4KO8, 5FTM, 6G30, 3QQ8, 3QQ7, 5FTN, 6G2W, 5GLF, 6G2Y, 6G2X, 4KLN

HMDB Protein

HMDBP11971

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNZ2 NSF1C			0.939	17
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.869	23
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425)	0.846	7
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.835	10
UniProt:P54252-1 ATXN3			0.833	18
UniProt:Q9BZV1 UBXN6			0.822	17
UniProt:P68543 UBX2A			0.811	13
UniProt:Q8TAT6 NPLOC4	1	NPLOC4 [nucleoplasm] (R-HSA-5654987)	0.774	6
UniProt:Q14CS0 UBX2B			0.755	10
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.748	17
UniProt:Q92890 UFD1	1	UFD1L [nucleoplasm] (R-HSA-5654993)	0.743	5
UniProt:Q96CS3 FAF2	2	FAF2 [azurophil granule lumen] (R-HSA-6799138) FAF2 [extracellular region] (R-HSA-6806183)	0.734	12
UniProt:Q92575 UBXN4			0.688	11
UniProt:Q96LJ8 UBX10			0.641	7
UniProt:O00124 UBXN8			0.641	8
UniProt:Q9UNN5-1 FAF1			0.618	4
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.573	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:Q13617 CUL2	3	CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.527	2
UniProt:B1AQ61 B1AQ61			0.525	4
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.524	2
UniProt:P26045 PTPN3	1	PTPN3 [plasma membrane] (R-HSA-5490317)	0.524	2
UniProt:Q5T124-6 UBXN11			0.524	7
UniProt:O94868 FCSD2			0.508	2
UniProt:Q9UNN5 FAF1			0.499	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.499	2
UniProt:Q9WTX6 Cul1	3	Cul1 [nucleoplasm] (R-MMU-9008723) G76-NEDD8-K720-CUL1 [cytosol] (R-MMU-8952519) CUL1 [cytosol] (R-MMU-174230)	0.499	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.499	2
UniProt:Q969W3 F104A			0.488	2
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q9Y263 PLAP			0.488	2
UniProt:O60941-5 DTNB			0.488	2
UniProt:Q96LK0 CEP19			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:O94941 UBOX5	1	UBOX5 [cytosol] (R-HSA-976034)	0.488	2
UniProt:P24278 ZBT25			0.488	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.488	2
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.488	2
UniProt:Q9H7H0-2 METTL17			0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:P0CG30 GSTT2B	1	GSTT2B [cytosol] (R-HSA-3302073)	0.488	2
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.488	2
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.488	2
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.462	2
UniProt:P04578-PRO_0000038428 ENV			0.462	2