EGFRvIII does not bind CBL

Stable Identifier
R-HSA-5637794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In EGFRvIII mutant, Y1045 (Y1069) is not phosphorylated (Han et al. 2006, Grandal et al. 2007). Han et al. detected no CBL binding to EGFRvIII mutant (Han et al. 2006), while Grandal et al. detected very little binding, which they explained by indirect recruitment of CBL to EGFRvIII through GRB2 (Grandal et al. 2007).

Literature References
PubMed ID Title Journal Year
17372273 EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

Grandal, MV, Zandi, R, Pedersen, MW, Willumsen, BM, van Deurs, B, Poulsen, HS

Carcinogenesis 2007
16969069 Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII

Han, W, Zhang, T, Yu, H, Foulke, JG, Tang, CK

Cancer Biol Ther 2006
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created