Reactome | GNB2L1 binds IKKA:IKKB:NEMO

GNB2L1 binds IKKA:IKKB:NEMO

Stable Identifier

R-HSA-5626962

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RACK1 binds IKKA:IKKB:NEMO

ReviewStatus

5/5

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Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1) also known as receptor of activated protein kinase C 1 (RACK1) is reported to associate with the IKK complex in a TNF-triggered manner (Yao F et al. 2014). This interaction interfered with TRAF2-mediated recruitment and the subsequent phosphorylation of IKK triggered by TNF. By modulating the interaction between TRAF2 and the IKK complex, GNB2L1 (RACK1) regulated the level of NFkB activation in response to TNF (Yao F et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24323043	RACK1 modulates NF-?B activation by interfering with the interaction between TRAF2 and the IKK complex Ying, GY, Bao, WD, Deng, YZ, Xie, D, Feng, YY, Zhu, YQ, Yao, F, Long, LY, Guan, DX, Li, G, Li, JJ	Cell Res.	2014