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PKN1 stimulates association of AR with NCOA2
Stable Identifier
R-HSA-5625745
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
PKN1 stimulates association of AR with NCOA2 (Homo sapiens)
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Binding of PKN1 to androgen-activated AR (androgen receptor) promotes the formation of a functional complex of AR with the transcriptional coactivator NCOA2 (TIF2) (Metzger et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
12514133
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
Schüle, R
,
Metzger, E
,
Müller, JM
,
Ferrari, S
,
Buettner, R
EMBO J.
2003
Participants
Input
NCOA2 [nucleoplasm]
(Homo sapiens)
p-T774-PKN1:AR:Androgen [nucleoplasm]
(Homo sapiens)
Output
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Orthologous Events
PKN1 stimulates association of AR with NCOA2 (Bos taurus)
PKN1 stimulates association of AR with NCOA2 (Canis familiaris)
PKN1 stimulates association of AR with NCOA2 (Danio rerio)
PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)
PKN1 stimulates association of AR with NCOA2 (Mus musculus)
PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)
PKN1 stimulates association of AR with NCOA2 (Sus scrofa)
Authored
Orlic-Milacic, M (2014-10-24)
Rivero Crespo, F (2014-12-26)
Created
Orlic-Milacic, M (2014-10-07)
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