HOXB1 gene is transcribed

Stable Identifier
R-HSA-5617454
Type
Reaction [omitted]
Species
Homo sapiens
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After activation by retinoic acid, the HOXB1 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in human embryonal carcinoma cells in Simeone et al. 1990, Ogura and Evans 1995).
In mouse embryos, Hoxb1 is expressed in mesoderm and neurectoderm of primitive streak stage embryos and then becomes restricted to rhombomeres of the hindbrain. Before rhombomere formation Hoxb1 is initially expressed in the region that becomes r3-7. After rhombomere formation Hoxb1 becomes restricted to r4 and is also observed in caudal mesoderm.

Literature References
PubMed ID Title Journal Year
7831296 A retinoic acid-triggered cascade of HOXB1 gene activation

Ogura, T, Evans, RM

Proc. Natl. Acad. Sci. U.S.A. 1995
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Giampaolo, A, Acampora, D, Zappavigna, V, Pannese, M, D'Esposito, M, Carè, A, Faiella, A, Stornaiuolo, A, Russo, G, Simeone, A

Differentiation 1989
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Simeone, A, Acampora, D, Arcioni, L, Andrews, PW, Boncinelli, E, Mavilio, F

Nature 1990
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