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TUBB2A [axonemal microtubule]
Stable Identifier
R-HSA-5610431
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
axonemal microtubule
Synonyms
beta tubulin 2A
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Intraflagellar transport (Homo sapiens)
Anterograde IFT (Homo sapiens)
anterograde IFT trains [ciliary tip] (Homo sapiens)
active kinesin-2 motors [ciliary tip] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
anterograde IFT trains [cilium] (Homo sapiens)
active kinesin-2 motors [cilium] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
Assembly of the anterograde IFT train (Homo sapiens)
active kinesin-2 motors [cilium] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
anterograde IFT trains [cilium] (Homo sapiens)
active kinesin-2 motors [cilium] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
Assembly of the retrograde IFT train (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
retrograde IFT trains [ciliary tip] (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
Retrograde IFT (Homo sapiens)
retrograde IFT trains [ciliary tip] (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
retrograde IFT trains [cilium] (Homo sapiens)
active dynein-2 motors [cilium] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
The anterograde IFT train dissociates (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
anterograde IFT trains [ciliary tip] (Homo sapiens)
active kinesin-2 motors [ciliary tip] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
The retrograde IFT train dissociates (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
retrograde IFT trains [cilium] (Homo sapiens)
active dynein-2 motors [cilium] (Homo sapiens)
acetylated microtubule [axonemal microtubule] (Homo sapiens)
Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)
KIF7:microtubule [ciliary tip] (Homo sapiens)
microtubule [axonemal microtubule] (Homo sapiens)
alpha-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
microtubule [axonemal microtubule] (Homo sapiens)
alpha-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)
KIF7:microtubule [ciliary tip] (Homo sapiens)
microtubule [axonemal microtubule] (Homo sapiens)
alpha-beta tubulin dimer [axonemal microtubule] (Homo sapiens)
beta tubulin:GDP [axonemal microtubule] (Homo sapiens)
beta tubulin [axonemal microtubule] (Homo sapiens)
TUBB2A [axonemal microtubule] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13885 TUBB2A
Gene Names
TUBB2A, TUBB2
Chain
chain:1-445
Reference Genes
BioGPS Gene:7280 TUBB2A
COSMIC (genes):TUBB2A TUBB2A
CTD Gene:7280 TUBB2A
dbSNP Gene:7280 TUBB2A
ENSEMBL:ENSG00000137267 TUBB2A
HGNC:12412 TUBB2A
KEGG Gene (Homo sapiens):7280 TUBB2A
Monarch:7280 TUBB2A
NCBI Gene:7280 TUBB2A
OMIM:615101 TUBB2A
UCSC:Q13885 TUBB2A
Reference Transcript
RefSeq:NM_001069.2 TUBB2A
RefSeq:NM_001310315.1 TUBB2A
Other Identifiers
0001190129
0001570161
11719788_s_at
11719789_x_at
15339
17015143
202154_x_at
204141_at
209372_x_at
213476_3p_x_at
213476_x_at
2939214
2939215
2939216
2939217
2939218
2939221
2939223
2939224
2939225
2939226
2939235
2939236
2939239
2939240
2939246
2939256
296_at
297_g_at
33678_i_at
39331_at
4050505
429_f_at
43640
46280
471_f_at
7280
8123644
A_23_P19291
A_23_P501276
AAH01194
AAH18780
AAN85571
AL031963
AY159127
BC001194
BC018780
CAA56071
CAB015339
CAG46756
CCDS4484
CR541958
ENSG00000137267
ENSP00000369703
ENST00000333628
ENST00000333628.3
EntrezGene:7280
EntrezGene:TUBB2A
g4507728_3p_at
GE79068
GO:0000166
GO:0000226
GO:0000278
GO:0001764
GO:0003674
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007049
GO:0008150
GO:0030154
GO:0040011
GO:0043167
GO:0043226
GO:0048856
GO:0048870
GO:0070062
GO:1903561
HGNC:12412
HPA043640
HPA046280
Hs.179661.3.S1_3p_x_at
ILMN_1343292
ILMN_2038775
ILMN_2044813
IPR000217
IPR002453
IPR003008
IPR008280
IPR013838
IPR017975
IPR018316
IPR023123
IPR036525
IPR037103
MIM:615101
MIM:615763
NM_001069
NM_001310315
NP_001060
NP_001297244
PF00091
PF03953
PH_hs_0026825
PR01161
PR01163
SM00864
SM00865
TC06001226.hg
TC06003365.hg
TC06003368.hg
TC06003369.hg
TUBB2A
TUBB2A-201
UPI000000DC98
X79535
Participant Of
hasCandidate
beta tubulin [axonemal microtubule]
Other forms of this molecule
TUBB2A folding intermediate [cytosol]
TUBB2A unfolded [cytosol]
Polyglycyl-TUBB2A [cytosol]
Polyglutamyl-TUBB2A [cytosol]
TUBB2A [cytosol]
Inferred To
Homologues of TUBB4B [axonemal microtubule] (Plasmodium falciparum)
TUBB2A [axonemal microtubule] (Bos taurus)
TUBB2A [axonemal microtubule] (Gallus gallus)
TUBB2A [axonemal microtubule] (Mus musculus)
TUBB2A [axonemal microtubule] (Rattus norvegicus)
TUBB2A [axonemal microtubule] (Sus scrofa)
TUBB2A [axonemal microtubule] (Xenopus tropicalis)
TUBB4B [axonemal microtubule] (Dictyostelium discoideum)
TUBB4B [axonemal microtubule] (Plasmodium falciparum)
TUBB4B [axonemal microtubule] (Saccharomyces cerevisiae)
TUBB4B [axonemal microtubule] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001297244.1
,
NP_001060.1
OpenTargets
ENSG00000137267
GeneCards
Q13885
PRO
Q13885
Orphanet
25007
HMDB Protein
HMDBP08602
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.547
3
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