Reactome | SUFU [ciliary tip]

SUFU [ciliary tip]

Stable Identifier

R-HSA-5610426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

Synonyms

Suppressor of fused homolog, SUFU_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q13515 BFSP2

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External Reference Information

External Reference

UniProt:Q9UMX1 SUFU

Gene Names

SUFU, UNQ650/PRO1280

Chain

chain:1-484

Reference Genes

BioGPS Gene:51684 SUFU

COSMIC (genes):SUFU SUFU

CTD Gene:51684 SUFU

dbSNP Gene:51684 SUFU

ENSEMBL:ENSG00000107882 SUFU

HGNC:16466 SUFU

KEGG Gene (Homo sapiens):51684 SUFU

Monarch:51684 SUFU

NCBI Gene:51684 SUFU

OMIM:607035 SUFU

UCSC:Q9UMX1 SUFU

Reference Transcript

Other Identifiers

0002510528

11721036_at

11721037_a_at

11721038_at

11744963_a_at

11759802_at

11762006_at

16708699

1M1L

222749_at

224201_s_at

224202_at

224203_at

3261766

3261767

3261770

3261776

3261786

3261787

3261788

3261789

3261790

3261795

3261796

3261797

3261798

3261799

3261800

3261801

3261802

3261803

3261807

3261809

3261810

3261811

3261819

3261821

3261822

3261823

49463_at

4BL8

4BL9

4BLA

4BLB

4BLD

4KM8

4KM9

4KMD

4KMH

51684

7930120

8700

A_14_P117713

A_14_P120695

A_23_P425304

A_24_P149893

A_24_P149902

A_33_P3333030

AAD50501

AAD51655

AAF23890

AAF23893

AAF35866

AAH13291

AAM08947

AAQ88914

AF144231

AF159447

AF172319

AF175770

AF222345

AL121928

AL137465

AL157386

AL391121

AY081818

AY081819

AY081820

AY081821

AY081822

AY081823

AY081824

AY081825

AY081826

AY081827

AY081828

AY081829

AY358550

BC013291

CAB70752

CCDS53571

CCDS7537

ENSG00000107882

ENSP00000358915

ENSP00000358918

ENSP00000411597

ENST00000369899

ENST00000369899.6

ENST00000369902

ENST00000369902.7

ENST00000423559

ENST00000423559.2

EntrezGene:51684

EntrezGene:SUFU

g6689887_3p_at

g6689893_3p_at

g7025391_3p_at

GE56721

GE82086

GE83749

GO:0000122

GO:0001501

GO:0001843

GO:0001947

GO:0003281

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005929

GO:0006355

GO:0006508

GO:0006810

GO:0006913

GO:0007165

GO:0007275

GO:0007368

GO:0008013

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0015031

GO:0019899

GO:0019901

GO:0021513

GO:0021775

GO:0021776

GO:0030154

GO:0034641

GO:0035904

GO:0042308

GO:0042994

GO:0043226

GO:0043433

GO:0043588

GO:0045668

GO:0045879

GO:0048646

GO:0048856

GO:0060976

GO:0097542

GO:0097546

GO:1901621

GO:2000059

HGNC:16466

HPA008700

ILMN_1691283

ILMN_1804361

IPR007768

IPR016591

IPR020941

IPR024314

IPR037181

IPR038489

LRG_521

LRG_521t1

MIM:109400

MIM:155255

MIM:607035

MIM:607174

MIM:617757

NM_001178133

NM_016169

NP_001171604

NP_057253

PF05076

PF12470

PH_hs_0001856

SUFU

SUFU-201

SUFU-202

SUFU-203

TC10000759.hg

UPI000004C5FF

UPI000006D11C

UPI0000073C79

XM_011539858

XM_011539860

XM_011539861

XM_011539863

XM_011539864

XM_017016323

XP_011538160

XP_011538162

XP_011538163

XP_011538165

XP_011538166

XP_016871812

Participant Of

output

hasComponent

Other forms of this molecule

SUFU [ciliary base]

SUFU [cytosol]

Inferred To

SUFU [ciliary tip] (Bos taurus)

SUFU [ciliary tip] (Canis familiaris)

SUFU [ciliary tip] (Danio rerio)

SUFU [ciliary tip] (Drosophila melanogaster)

SUFU [ciliary tip] (Gallus gallus)

SUFU [ciliary tip] (Mus musculus)

SUFU [ciliary tip] (Rattus norvegicus)

SUFU [ciliary tip] (Sus scrofa)

SUFU [ciliary tip] (Xenopus tropicalis)

Cross References

RefSeq

NP_001171604.1, NP_057253.2

OpenTargets

ENSG00000107882

GeneCards

Q9UMX1

PRO

Q9UMX1

Orphanet

15569

PDB

4BLB, 4BL9, 4KMD, 4BLA, 4KM9, 4KM8, 4BLD, 4BL8, 1M1L, 4KMH

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08151 GLI1	9	GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040) GLI1 [cytosol] (R-HSA-445457) pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833)	0.943	25
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.712	4
UniProt:P10071 GLI3	13	GLI3R [cytosol] (R-HSA-5610369) GLI3R [nucleoplasm] (R-HSA-5610371) ub-p13S-GLI3 [ciliary base] (R-HSA-5610506) p13S-GLI3 [ciliary base] (R-HSA-5610485) p10S-GLI3 [ciliary base] (R-HSA-5610454) p6S-GLI3 [ciliary base] (R-HSA-5610492) GLI3 [ciliary base] (R-HSA-5610365) GLI3 [ciliary tip] (R-HSA-5610367) p-GLI3 [nucleoplasm] (R-HSA-5635051) 2p-GLI3 [nucleoplasm] (R-HSA-5635052) p-GLI3 [ciliary tip] (R-HSA-5635048) GLI3 [cytosol] (R-HSA-206085) ub-2p-GLI3 [nucleoplasm] (R-HSA-5635060)	0.683	3
UniProt:Q96D15 RCN3			0.675	4
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.666	4
UniProt:Q13515 BFSP2			0.621	3
UniProt:Q9NWS9-2 ZNF446			0.621	3
UniProt:Q9NRP7 STK36			0.589	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.553	2
UniProt:Q7Z412 PEX26	2	PEX26 [peroxisomal membrane] (R-HSA-9033092) PEX26 [cytosol] (R-HSA-9603779)	0.508	2
UniProt:Q7Z353 HDX			0.488	2
UniProt:Q96JM7-2 L3MBTL3			0.488	2
UniProt:Q9Y250 LZTS1			0.488	2
UniProt:Q53ET0 CRTC2	1	CRTC2 [nucleoplasm] (R-HSA-8931951)	0.488	2
UniProt:Q8TBC5 ZSC18			0.488	2
UniProt:Q8NC26 ZNF114	1	ZNF114 [nucleoplasm] (R-HSA-975026)	0.488	2
UniProt:P51114-2 FXR1			0.488	2
UniProt:Q8N4C7 STX19			0.488	2
UniProt:Q0D2J5 ZN763			0.488	2
UniProt:Q15915 ZIC1			0.488	2
UniProt:Q86VQ0 LCA5			0.488	2
UniProt:Q9P2A4 ABI3			0.488	2
UniProt:Q9Y3S2 ZN330			0.488	2
UniProt:Q9UJ55 MAGL2			0.488	2
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.488	2
IntAct:EBI-11958528 SH3RF1			0.488	2
UniProt:Q6FHY5 Q6FHY5			0.488	2
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.488	2
UniProt:Q9NRI5-2 DISC1			0.488	2
UniProt:Q96GZ6 S41A3			0.488	2
UniProt:O43186 CRX			0.488	2
UniProt:P78411 IRX5			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q0VGT2 Gli2	13	Gli2 [cytosol] (R-MMU-5610376) phospho-ub-2p-GLI2 [nucleoplasm] (R-MMU-5635059) p4S-Gli2 [cytosol] (R-MMU-5610489) p8S-Gli2 [cytosol] (R-MMU-5610496) p11S-Gli2 [cytosol] (R-MMU-5610476) ub-p11S-Gli2 [cytosol] (R-MMU-5610503) GLI2 [cytosol] (R-MMU-445451) phospho-p-GLI2 [ciliary tip] (R-MMU-5635044) phospho-p-GLI2 [nucleoplasm] (R-MMU-5635047) Gli2 [nucleoplasm] (R-MMU-3900178) phospho-2p-GLI2 [nucleoplasm] (R-MMU-5635055) GLI2 [ciliary base] (R-MMU-5610361) GLI2 [ciliary tip] (R-MMU-5610363)	0.463	3