Reactome | PRKACB [ciliary base]

PRKACB [ciliary base]

Stable Identifier

R-HSA-5610404

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary base

Synonyms

cAMP-dependent protein kinase, beta-catalytic subunit , PKA C-beta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22694 PRKACB

Gene Names

PRKACB

Chain

initiator methionine:, chain:2-351

Reference Genes

BioGPS Gene:5567 PRKACB

COSMIC (genes):PRKACB PRKACB

CTD Gene:5567 PRKACB

dbSNP Gene:5567 PRKACB

ENSEMBL:ENSG00000142875 PRKACB

ENSEMBL_homo_sapiens_GENE:ENSG00000142875.21 PRKACB

HGNC:9381 PRKACB

KEGG Gene (Homo sapiens):5567 PRKACB

Monarch:5567 PRKACB

NCBI Gene:5567 PRKACB

OMIM:176892 PRKACB

UCSC:P22694 PRKACB

Reference Transcript

Other Identifiers

11716703_a_at

11735694_a_at

11754927_x_at

11755434_a_at

16666616

202741_PM_at

202741_at

202742_PM_s_at

202742_s_at

2344397

2344398

2344419

2344420

2344421

2344424

2344430

2344431

2344432

2344433

2344435

2344436

2344437

2344438

2344439

2344440

2344441

2344444

2344445

2344446

2344447

2344449

235780_PM_at

235780_at

36215_at

46322_at

5567

7902594

84201_r_at

A_14_P104414

A_14_P110390

A_14_P134402

A_23_P371410

A_24_P62708

A_33_P3215317

A_33_P3772996

GE57940

GO:0000166

GO:0000287

GO:0001843

GO:0003014

GO:0003091

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005952

GO:0006468

GO:0007165

GO:0007188

GO:0010737

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0031625

GO:0034380

GO:0036211

GO:0043226

GO:0045879

GO:0048856

GO:0051604

GO:0065003

GO:0070062

GO:0070613

GO:0097546

GO:0106310

GO:0140096

GO:1904262

HMNXSV003001255

HMNXSV003034107

Hs.165446.0.A1_3p_at

Hs.87773.0.S2_3p_at

ILMN_1690314

ILMN_1759922

ILMN_1771523

ILMN_2278112

ILMN_2374234

M34181_at

PH_hs_0040487

TC01004503.hg

g4506056_3p_a_at

Participates

as a member of

PKA catalytic subunit [ciliary base] (Homo sapiens)

Other forms of this molecule

PRKACB [cytosol]

PRKACB [nucleoplasm]

Inferred To

PRKACA [ciliary base] (Caenorhabditis elegans)

PRKACA [ciliary base] (Drosophila melanogaster)

PRKACA [ciliary base] (Saccharomyces cerevisiae)

PRKACA [ciliary base] (Schizosaccharomyces pombe)

Dmel\CG12069 [ciliary base] (Drosophila melanogaster)

PRKACB [ciliary base] (Bos taurus)

PRKACB [ciliary base] (Canis familiaris)

PRKACB [ciliary base] (Danio rerio)

PRKACB [ciliary base] (Drosophila melanogaster)

PRKACB [ciliary base] (Gallus gallus)

PRKACB [ciliary base] (Mus musculus)

PRKACB [ciliary base] (Rattus norvegicus)

PRKACB [ciliary base] (Saccharomyces cerevisiae)

PRKACB [ciliary base] (Sus scrofa)

Homologues of PRKACB [ciliary base] (Drosophila melanogaster)

Homologues of PRKACB [ciliary base] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001229788.1, NP_001287846.1, XP_006710821.1, NP_001229791.1, NP_001229790.1, NP_001229789.1, NP_891993.1, NP_001229786.1, NP_001229787.1, NP_001287844.1, NP_001287845.1, XP_005271076.1, NP_997461.1, NP_002722.1

ZINC - World Drugs

KAPCB_HUMAN

Guide to Pharmacology - Targets

1477

OpenTargets

ENSG00000142875

ZINC - FDA approved

KAPCB_HUMAN

ZINC - Substances

KAPCB_HUMAN

ZINC target

P22694

ZINC - Biogenic

KAPCB_HUMAN

PRO

P22694

ZINC - Investigational

KAPCB_HUMAN

IntEnz

2.7.11.11

GeneCards

P22694

HPA

ENSG00000142875-PRKACB

Ensembl

ENSP00000479722, ENSP00000359719, ENST00000370688, ENST00000370689, ENSP00000359722, ENSP00000359723, ENST00000446538, ENSP00000481980, ENSG00000142875, ENST00000610703, ENST00000614872, ENST00000394839, ENSP00000401252, ENSP00000378315, ENST00000370685

Pharos - Targets

P22694

ZINC - Predictions - Purchasable

KAPCB_HUMAN

HMDB Protein

HMDBP01415

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.643	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.643	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.527	2
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.527	4

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