Reactome | TRAF3 R118W [cytosol]

TRAF3 R118W [cytosol]

Stable Identifier

R-HSA-5602321

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:Q0D2K3 RIPP1

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Literature References

PubMed ID	Title	Journal	Year
20832341	Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis Pérez de Diego, R, Sancho-Shimizu, V, Lorenzo, L, Puel, A, Plancoulaine, S, Picard, C, Herman, M, Cardon, A, Durandy, A, Bustamante, J, Vallabhapurapu, S, Bravo, J, Warnatz, K, Chaix, Y, Cascarrigny, F, Lebon, P, Rozenberg, F, Karin, M, Tardieu, M, Al-Muhsen, S, Jouanguy, E, Zhang, SY, Abel, L, Casanova, JL	Immunity	2010

External Reference Information

External Reference

UniProt:Q13114 TRAF3

Gene Names

TRAF3, CAP1, CRAF1

Chain

chain:1-568

Reference Genes

BioGPS Gene:7187 TRAF3

COSMIC (genes):TRAF3 TRAF3

CTD Gene:7187 TRAF3

dbSNP Gene:7187 TRAF3

ENSEMBL:ENSG00000131323 TRAF3

HGNC:12033 TRAF3

KEGG Gene (Homo sapiens):7187 TRAF3

Monarch:7187 TRAF3

NCBI Gene:7187 TRAF3

OMIM:601896 TRAF3

UCSC:Q13114 TRAF3

Reference Transcript

Other Identifiers

0000940739

11742091_a_at

11743501_a_at

11759502_at

16789080

1FLK

1FLL

1KZZ

1L0A

1RF3

1ZMS

208315_3p_x_at

208315_x_at

221571_at

2933

2ECY

2GKW

3553338

3553346

3553358

3553359

3553363

3553364

3553367

3553368

3553370

3553374

3553382

3553383

3553384

3553386

3553388

37057_s_at

43952_at

7187

7977018

A6NHG8

A_23_P37068

A_32_P89837

AAA56753

AAA65732

AAA68195

AAC50112

AAD29276

AAH75086

AAH75087

AF110908

AK303172

AL117209

BAH13910

BC075086

BC075087

BX247977

CAD62311

CCDS55946

CCDS9975

ENSG00000131323

ENSP00000328003

ENSP00000376500

ENSP00000445998

ENSP00000454207

ENST00000347662

ENST00000392745

ENST00000392745.6

ENST00000539721

ENST00000539721.5

ENST00000560371

ENST00000560371.5

EntrezGene:7187

EntrezGene:TRAF3

g4507678_3p_a_at

g4507678_3p_at

g4507678_3p_x_at

GE59008

GO:0001817

GO:0002224

GO:0002376

GO:0003674

GO:0004842

GO:0005164

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0006950

GO:0007165

GO:0008063

GO:0008150

GO:0008219

GO:0008270

GO:0009058

GO:0009898

GO:0016567

GO:0016579

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0030162

GO:0031410

GO:0031625

GO:0031996

GO:0032088

GO:0032648

GO:0032991

GO:0033209

GO:0034641

GO:0035631

GO:0035666

GO:0042981

GO:0043167

GO:0043226

GO:0045087

GO:0046872

GO:0050688

H0YL25

H0YL26

H0YMI8

HGNC:12033

HPA002933

Hs.297660.1.S2_3p_at

ILMN_1793154

ILMN_2383774

IPR001293

IPR001841

IPR002083

IPR008974

IPR012227

IPR013083

IPR017907

IPR027128

IPR037304

L38509

LRG_229

LRG_229t1

MIM:601896

MIM:614849

NM_001199427

NM_003300

NM_145725

NP_001186356

NP_003291

NP_663777

PF02176

PH_hs_0015383

PH_hs_0038599

SM00061

TC14000786.hg

TRAF3

TRAF3-203

TRAF3-204

TRAF3-208

U15637

U15637_s_at

U19260

U21092

UPI000000CBF9

UPI0001E88EE1

XM_011537118

XM_017021617

XM_017021618

XP_011535420

XP_016877106

XP_016877107

Participant Of

input

Defective TRAF3 does not transmit the signal

Other forms of this molecule

K63polyUb-TRAF3 [cytosol]

TRAF3 [cytosol]

K48polyUb-TRAF3 [cytosol]

Modified Residues

Name

L-arginine 118 replaced with L-tryptophan

Coordinate

118

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

L-tryptophan residue [MOD:00027]

A protein modification that effectively converts a source amino acid residue to L-tryptophan.

Disease

Name	Identifier	Synonyms
primary immunodeficiency disease	612	immune deficiency disorder, immunodeficiency syndrome, hypoimmunity

Cross References

RefSeq

XP_011535420.1, NP_001186356.1, NP_003291.2, XP_016877107.1, XP_016877106.1, NP_663777.1, NP_663778.1

OpenTargets

ENSG00000131323

GeneCards

Q13114

PRO

Q13114

Orphanet

20819

PDB

1RF3, 2GKW, 1KZZ, 1ZMS, 2ECY, 1FLK, 1L0A, 1FLL

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99558 MAP3K14	5	K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531) p-MAP3K14 [cytosol] (R-HSA-168187) MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646)	0.783	5
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.77	6
UniProt:Q13546 RIPK1	9	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) p-S-RIPK1 [cytosol] (R-HSA-5218872) RIPK1 [cytosol] (R-HSA-168651) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021)	0.675	4
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [cilium] (R-HSA-5617603) TRAF3IP1 [ciliary tip] (R-HSA-5625404)	0.639	8
UniProt:O00463 TRAF5			0.635	3
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.633	5
UniProt:O95721 SNAP29	3	SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997) SNAP29 [azurophil granule membrane] (R-HSA-6799359)	0.621	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.564	2
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.564	2
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.547	2
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2 [cytosol] (R-HSA-50847) BIRC2(373-618) [cytosol] (R-HSA-202931)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.524	2
UniProt:P25942 CD40			0.508	3
UniProt:Q9QYP6 AZI2			0.499	2
UniProt:P15314	1	IRF1 [nucleoplasm] (R-MMU-983456)	0.499	2
UniProt:A2APF7 A2APF7			0.499	2
UniProt:Q52MB2 CC184			0.488	2
UniProt:Q5T681 CJ062			0.488	2
UniProt:Q8IYE1 CCD13			0.488	2
UniProt:Q6ZSB9 ZBT49			0.488	2
UniProt:Q7KZS0 Q7KZS0			0.488	2
UniProt:Q8NAM6 ZSCA4			0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q8N9N2-2 ASCC1			0.488	2
UniProt:Q9UKD1 GMEB2			0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2
UniProt:Q13114 TRAF3	5	TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) K48polyUb-TRAF3 [cytosol] (R-HSA-5668444) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.488	2
UniProt:Q86UB2 BIVM			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:Q0D2K3 RIPP1			0.488	2
UniProt:P28062-2 PSMB8			0.488	2
IntAct:EBI-12191689 HEMGN			0.488	2
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.488	2
UniProt:Q17RL8 Q17RL8			0.488	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.488	2
UniProt:Q96HA1-2 POM121			0.488	2
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.488	4
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:Q9Y547 HSPB11	2	HSPB11 [cilium] (R-HSA-5617628) HSPB11 [ciliary tip] (R-HSA-5625342)	0.488	2
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.488	2