NCOA2(869-1464) binds KAT6A(1-1118)

Stable Identifier
R-HSA-5579023
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
NCOA2:KAT6A fusion protein causes acute myeloid leukemias
ReviewStatus
5/5
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Chromosomal aberrations involving nuclear receptor coactivator 2 (NCOA2) and histone acetyltransferase KAT6A (KAT6A aka MOZ) may be a cause of acute myeloid leukemias. Inversion inv8(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation (Carapeti et al. 1998).
Literature References
PubMed ID Title Journal Year
9558366 A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia

Goldman, JM, Aguiar, RC, Carapeti, M, Cross, NC

Blood 1998
Participants
Participates
Orthologous Events
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