Defective Mismatch Repair Associated With MLH1

Stable Identifier
R-HSA-5545483
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Defective Mismatch Repair Associated With MLH1
Click the image above or here to open this pathway in the Pathway Browser
The MLH1:PMS2 complex is homologous to the E. coli MutL gene and is involved in DNA mismatch repair. Heterozygous mutations in the MLH1 gene result in hereditary nonpolyposis colorectal cancer-2 (Papadopoulos et al., 1994).
Literature References
PubMed ID Title Journal Year
12419761 Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review

Dunlop, MG, Farrington, SM, Mitchell, RJ, Campbell, H

Am. J. Epidemiol. 2002
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Gillespie, ME  (2011-11-10)
Reviewed
Arora, S  (2016-11-01)
Created
Gillespie, ME  (2014-05-21)
Cite Us!