Formation of MSH1:PMS2 Complex

Stable Identifier
R-HSA-5444523
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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Formation of MSH1:PMS2 Complex
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The heterodimer of MLH1 and PMS2 and is required for mismatch repair. The complex is known as MutL with mutations causing deficiencies in DNA mismatch repair.

Literature References
PubMed ID Title Journal Year
8128251 Mutation of a mutL homolog in hereditary colon cancer

Papadopoulos, N, Nicolaides, NC, Wei, YF, Ruben, SM, Carter, KC, Rosen, CA, Haseltine, WA, Fleischmann, RD, Fraser, CM, Adams, MD

Science 1994
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Orthologous Events
Formation of MSH1:PMS2 Complex (Bos taurus)
Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)
Formation of MSH1:PMS2 Complex (Canis familiaris)
Formation of MSH1:PMS2 Complex (Danio rerio)
Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)
Formation of MSH1:PMS2 Complex (Drosophila melanogaster)
Formation of MSH1:PMS2 Complex (Gallus gallus)
Formation of MSH1:PMS2 Complex (Mus musculus)
Formation of MSH1:PMS2 Complex (Plasmodium falciparum)
Formation of MSH1:PMS2 Complex (Rattus norvegicus)
Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)
Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)
Formation of MSH1:PMS2 Complex (Sus scrofa)
Formation of MSH1:PMS2 Complex (Xenopus tropicalis)
Authored
Gillespie, ME  (2014-05-09)
Reviewed
Edelbrock, MA  (2014-05-23)
Created
Gillespie, ME  (2014-05-14)