Formation of MSH2:MSH6 Complex

Stable Identifier
R-HSA-5444516
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MSH2 and MSH6 are mismatch DNA repair genes that act together as a heterodimer. The MSH6 subunit is responsible for binding the mismatch, which activates MSH2:MSH6 to exchange ADP for ATP, adopt the conformation to allow movement on the DNA, and interact with downstream effectors.

Literature References
PubMed ID Title Journal Year
8128251 Mutation of a mutL homolog in hereditary colon cancer

Papadopoulos, N, Nicolaides, NC, Wei, YF, Ruben, SM, Carter, KC, Rosen, CA, Haseltine, WA, Fleischmann, RD, Fraser, CM, Adams, MD

Science 1994
Participants
Participant Of
Orthologous Events
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Created