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NR1H4 [nucleoplasm]
Stable Identifier
R-HSA-5340228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bile acid receptor, NR1H4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RI1 NR1H4
Gene Names
NR1H4, BAR, FXR, HRR1, RIP14
Chain
chain:1-486
Reference Genes
BioGPS Gene:9971 NR1H4
COSMIC (genes):NR1H4 NR1H4
CTD Gene:9971 NR1H4
dbSNP Gene:9971 NR1H4
ENSEMBL:ENSG00000012504 NR1H4
ENSEMBL_homo_sapiens_GENE:ENSG00000012504.15 NR1H4
HGNC:7967 NR1H4
KEGG Gene (Homo sapiens):9971 NR1H4
Monarch:9971 NR1H4
NCBI Gene:9971 NR1H4
OMIM:603826 NR1H4
UCSC:Q96RI1 NR1H4
Reference Transcript
RefSeq:NM_005123.3 NR1H4
RefSeq:NM_001206977.1 NR1H4
RefSeq:NM_001206992.1 NR1H4
RefSeq:NM_001206978.1 NR1H4
RefSeq:NM_001206979.1 NR1H4
RefSeq:XM_011539040.2 NR1H4
RefSeq:NM_001206993.1 NR1H4
Other Identifiers
11756222_a_at
1554375_PM_a_at
1554375_a_at
16755671
206340_PM_at
206340_at
3428224
3428226
3428228
3428229
3428230
3428231
3428237
3428242
3428253
3428255
3428256
3428257
3428258
3428262
3428263
3428264
3428265
38519_at
7957835
9971
A_14_P109817
A_14_P137520
A_23_P25396
GE59358
GO:0000122
GO:0000785
GO:0000791
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001080
GO:0001221
GO:0001228
GO:0001678
GO:0002376
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006520
GO:0006629
GO:0006954
GO:0007043
GO:0007219
GO:0008206
GO:0008270
GO:0008289
GO:0010804
GO:0010903
GO:0010988
GO:0012501
GO:0016922
GO:0023052
GO:0030154
GO:0030522
GO:0032052
GO:0032689
GO:0032692
GO:0032703
GO:0032715
GO:0032720
GO:0032740
GO:0034162
GO:0034255
GO:0034330
GO:0035356
GO:0035774
GO:0038181
GO:0038183
GO:0038185
GO:0042593
GO:0042632
GO:0042742
GO:0043066
GO:0043124
GO:0043226
GO:0043235
GO:0043565
GO:0045087
GO:0045893
GO:0045944
GO:0046628
GO:0046872
GO:0046965
GO:0048856
GO:0050728
GO:0055089
GO:0060089
GO:0061178
GO:0070328
GO:0070857
GO:0071222
GO:0071398
GO:0071417
GO:0071638
GO:0071941
GO:0090181
GO:0098542
GO:0140110
GO:1902122
GO:1903413
GO:1904179
GO:1905695
GO:2000213
GO:2001250
HMNXSV003015333
HMNXSV003020171
HMNXSV003039909
Hs2.171683.2.S1_3p_s_at
ILMN_1708391
PH_hs_0022500
TC12000778.hg
U68233_at
g4826979_3p_at
Participates
as an input of
NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)
as a component of
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
Inferred To
nr1h4 [nucleoplasm]
(Xenopus tropicalis)
FXR [nucleoplasm]
(Gallus gallus)
EcR [nucleoplasm]
(Drosophila melanogaster)
NR1H4 [nucleoplasm]
(Bos taurus)
NR1H4 [nucleoplasm]
(Canis familiaris)
NR1H4 [nucleoplasm]
(Mus musculus)
NR1H4 [nucleoplasm]
(Rattus norvegicus)
NR1H4 [nucleoplasm]
(Sus scrofa)
zgc:92742 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001193907.1
,
NP_001193908.1
,
NP_001193921.1
,
NP_001193922.1
,
NP_005114.1
,
NP_001193906.1
,
XP_011537342.1
ZINC - World Drugs
NR1H4_HUMAN
Guide to Pharmacology - Targets
603
OpenTargets
ENSG00000012504
ZINC - FDA approved
NR1H4_HUMAN
ZINC - Substances
NR1H4_HUMAN
ZINC target
Q96RI1
ZINC - Biogenic
NR1H4_HUMAN
PRO
Q96RI1
PDB
3GD2
,
5Q13
,
5Q1C
,
5Q1H
,
5Q1A
,
6HL1
,
7TRB
,
5Q10
,
5Q1G
,
5Q0K
,
8HBM
,
3P89
,
5Q17
,
5Q0P
,
3RUT
,
3FLI
,
3OMK
,
5Q11
,
6A5Z
,
1OSH
,
7D42
,
3HC6
,
5Q14
,
6A5X
,
6A60
,
6HL0
,
4WVD
,
5Q19
,
3RVF
,
5Q1B
,
5Q16
,
7VUE
,
5Q0L
,
5Q0V
,
5Q1F
,
5Q0O
,
5Q0J
,
3DCU
,
5Q0W
,
5Q0Q
,
3RUU
,
3P88
,
5Q0S
,
5Q1I
,
3OMM
,
3OOF
,
5Q18
,
3OKH
,
5Q0Z
,
5Z12
,
6A5Y
,
3HC5
,
5Q15
,
5Q1E
,
6A5W
,
5YXL
,
3OLF
,
4OIV
,
5YXD
,
5Q0I
,
5Q0N
,
5Y44
,
3DCT
,
4QE8
,
3OOK
,
3OKI
,
6ITM
,
5WZX
,
5IAW
,
3L1B
,
5Q12
,
5Q0M
,
5YXJ
,
5Q1D
,
3FXV
,
5YXB
,
5ICK
,
5Q0X
,
5Y1J
,
5Q0U
,
5Q0T
,
5Y49
,
5Q0R
,
5Q0Y
,
3BEJ
ZINC - Investigational
NR1H4_HUMAN
ZINC - Metabolites
NR1H4_HUMAN
HPA
ENSG00000012504-NR1H4
GeneCards
Q96RI1
Ensembl
ENST00000648861
,
ENSP00000447149
,
ENSP00000448506
,
ENSP00000496908
,
ENST00000188403
,
ENSP00000448978
,
ENST00000392986
,
ENSP00000376712
,
ENST00000549996
,
ENST00000548884
,
ENSG00000012504
,
ENST00000551379
,
ENSP00000188403
Pharos - Targets
Q96RI1
ZINC - Predictions - Purchasable
NR1H4_HUMAN
Orphanet
21199
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.633
5
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.558
4
UniProt:FGF19 ENSG00000162344
0.527
2
UniProt:O75151 PHF2
1
PHF2 [nucleoplasm]
(R-HSA-5423093)
0.525
2
IntAct:EBI-11173936 P2
0.524
4
IntAct:EBI-11173957 P4
0.524
4
IntAct:EBI-11173879 P1
0.524
4
IntAct:EBI-11173918 IR1
0.524
2
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