CLAT:AP1:CLVS bind PI(3,5)P2

Stable Identifier
R-HSA-5333658
Type
Reaction [binding]
Species
Homo sapiens
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Clathrin-coated vesicles (CCVs) originating from the trans-Golgi network (TGN) provide a major transport pathway from the secretory system to endosomes/lysosomes. Clavesin 1 and 2 (CLVS1 and 2) are enriched on CCVs and form a complex with clathrin heavy chain (CHC) and adaptor protein-1 (AP1) complex, major coat components of TGN-derived CCVs. The complex can bind phosphatidylinositol 3,5-bisphosphate (PIP2), a phospholipid localised to late endosomes and lysosomes. This interaction is thought to assist the transport of cytosolic cargo proteins to the endosomal network (Katoh et al. 2009).

Literature References
PubMed ID Title Journal Year
19651769 The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology

Katoh, Y, Ritter, B, Gaffry, T, Blondeau, F, Höning, S, McPherson, PS

J. Biol. Chem. 2009
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