PIAS1,4 SUMOylate CASP8AP2 with SUMO1

Stable Identifier
R-HSA-5228521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
PIAS1,PIAS4 SUMOylate FLASH
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1, PIAS4 SUMOylate CASP8AP2 (FLASH) at lysine-1813 with SUMO1 (Alm-Kristiansen et al. 2009, Alm-Kristiansen et al. 2011). SUMOylation enhances the transcriptional coactivation activity of CASP8AP2. As inferred from mouse homologs, SUMOylation also appears to trigger proteasomal degradation of CASP8AP2 (Vennemann and Hofmann 2013).

Literature References
PubMed ID Title Journal Year
21338522 PIAS1 interacts with FLASH and enhances its co-activation of c-Myb

Alm-Kristiansen, AH, Lorenzo, PI, Molværsmyr, AK, Matre, V, Ledsaak, M, Sæther, T, Gabrielsen, OS

Mol. Cancer 2011
23673342 SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

Vennemann, A, Hofmann, TG

Cell Cycle 2013
19615980 SUMO modification regulates the transcriptional activity of FLASH

Alm-Kristiansen, AH, Norman, IL, Matre, V, Gabrielsen, OS

Biochem. Biophys. Res. Commun. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created