Reactome | ABCF1 binds EIF2

ABCF1 binds EIF2

Stable Identifier

R-HSA-5227009

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ATP-binding cassette sub-family F member 1 (ABCF1 aka ABC50) is unlike most ABC proteins in that it does not possess membrane-spanning domains. ABCF1 interacts with eukaryotic initiation factor 2 complex (EIF2S1:EIF2S2:EIF2S3), a key player in translation initiation and control and in ribosome regulation. ABCF1 is predominantly located in the cytosol, whereas a smaller amount is also found in the nucleoplasm but not in the nucleolus. Knockout of ABCF1 impaired translation of both cap-dependent and cap-independent reporters, consistent with a positive role for ABCF1 in the function of the EIF2 complex (Paytubi et al. 2008, Paytubi et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19570978	ABC50 promotes translation initiation in mammalian cells Lam, YW, Jan, E, Proud, CG, Izquierdo, L, Wang, X, Hunter, MJ, Hundal, HS, Paytubi, S	J. Biol. Chem.	2009
17894550	The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2 Proud, CG, Morrice, NA, Paytubi, S, Boudeau, J	Biochem. J.	2008